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Structural analysis of the RSC chromatin-remodeling complex

Academic Article
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Overview

authors

  • Asturias, Francisco
  • Chung, W. H.
  • Kornberg, R. D.
  • Lorch, Y.

publication date

  • October 2002

journal

  • Proceedings of the National Academy of Sciences of the United States of America  Journal

abstract

  • Electron microscopy of the RSC chromatin-remodeling complex reveals a ring of protein densities around a central cavity. The size and shape of the cavity correspond closely to those of a nucleosome. Results of nuclease protection analysis are consistent with nucleosome binding in the cavity. Such binding could explain the ability of RSC to expose nucleosomal DNA in the presence of ATP without loss of associated histones.

subject areas

  • Adenosine Triphosphate
  • Animals
  • Chromatin
  • DNA-Binding Proteins
  • Histones
  • In Vitro Techniques
  • Macromolecular Substances
  • Microscopy, Electron
  • Molecular Structure
  • Nucleosomes
  • Rats
  • Saccharomyces cerevisiae Proteins
  • Transcription Factors
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Identity

PubMed Central ID

  • PMC129698

International Standard Serial Number (ISSN)

  • 0027-8424

Digital Object Identifier (DOI)

  • 10.1073/pnas.162504299

PubMed ID

  • 12368485
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Additional Document Info

start page

  • 13477

end page

  • 13480

volume

  • 99

issue

  • 21

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