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Undertaker, a Drosophila Junctophilin, links Draper-mediated phagocytosis and calcium homeostasis

Academic Article
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Overview

authors

  • Cuttell, L.
  • Vaughan, A.
  • Silva, E.
  • Escaron, C. J.
  • Lavine, M.
  • Van Goethem, E.
  • Eid, J. P.
  • Quirin, M.
  • Franc, Nathalie

publication date

  • October 2008

journal

  • Cell  Journal

abstract

  • Phagocytosis is important during development and in the immune response for the removal of apoptotic cells and pathogens, yet its molecular mechanisms are poorly understood. In Caenorhabditis elegans, the CED2/5/10/12 pathway regulates actin during phagocytosis of apoptotic cells, whereas the role of the CED1/6/7 pathway in phagocytosis is unclear. We report that Undertaker (UTA), a Drosophila Junctophilin protein, is required for Draper (CED-1 homolog)-mediated phagocytosis. Junctophilins couple Ca2+ channels at the plasma membrane to those of the endoplasmic reticulum (ER), the Ryanodine receptors. We place Draper, its adaptor drCed-6, UTA, the Ryanodine receptor Rya-r44F, the ER Ca2+ sensor dSTIM, and the Ca2+-release-activated Ca2+ channel dOrai in the same pathway that promotes calcium homeostasis and phagocytosis. Thus, our results implicate a Junctophilin in phagocytosis and link Draper-mediated phagocytosis to Ca2+ homeostasis, highlighting a previously uncharacterized role for the CED1/6/7 pathway.

subject areas

  • Animals
  • Animals, Genetically Modified
  • Apoptosis
  • Calcium
  • Drosophila Proteins
  • Drosophila melanogaster
  • Embryo, Nonmammalian
  • Membrane Proteins
  • Phagocytosis
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Identity

International Standard Serial Number (ISSN)

  • 0092-8674

Digital Object Identifier (DOI)

  • 10.1016/j.cell.2008.08.033

PubMed ID

  • 18984163
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Additional Document Info

start page

  • 524

end page

  • 534

volume

  • 135

issue

  • 3

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