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Participation of auto-anti-idiotypes in immune-complex glomerulonephritis in rabbits

Academic Article
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Overview

authors

  • Zanetti, M.
  • Wilson, Curtis

publication date

  • 1983

journal

  • Journal of Immunology  Journal

abstract

  • We report the presence of auto-anti-Id antibodies in the glomerular immune deposits of a rabbit with chronic serum sickness induced by daily i.v. injections of bovine serum albumin. Auto-anti-Id antibodies were also documented in the serum of the same animal during the phase of chronic serum sickness in which immune complex glomerulonephritis develops. These results suggest that auto-anti-Id may normally participate in pathologic reactions and may be one of the mechanisms of potentiation and/or progression of immunopathologic lesions.

subject areas

  • Animals
  • Antigen-Antibody Complex
  • Autoantibodies
  • Chronic Disease
  • Glomerulonephritis
  • Immune Complex Diseases
  • Immunoglobulin Idiotypes
  • Rabbits
  • Serum Albumin, Bovine
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Identity

International Standard Serial Number (ISSN)

  • 0022-1767

PubMed ID

  • 6227667
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Additional Document Info

start page

  • 2781

end page

  • 2783

volume

  • 131

issue

  • 6

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