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Broad hiv-1 neutralization mediated by cd4-binding site antibodies

Academic Article
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Overview

authors

  • Li, Yuxing
  • Migueles, S. A.
  • Welcher, B.
  • Svehla, K.
  • Phogat, A.
  • Louder, M. K.
  • Wu, X.
  • Shaw, G. M.
  • Connors, M.
  • Wyatt, Richard
  • Mascola, J. R.

publication date

  • September 2007

journal

  • Nature Medicine  Journal

abstract

  • We have identified several patient sera showing potent and broad HIV-1 neutralization. Using antibody adsorption and elution from selected gp120 variants, the neutralizing specificities of the two most broadly reactive sera were mapped to the primary receptor CD4-binding region of HIV-1 gp120. Novel antibodies to the CD4-binding site are elicited in some HIV-1-infected individuals, and new approaches to present this conserved region of gp120 to the immune system may result in improved vaccine immunogens.

subject areas

  • Acquired Immunodeficiency Syndrome
  • Antigens, CD
  • Antigens, CD4
  • Binding Sites, Antibody
  • Cohort Studies
  • HIV Antibodies
  • HIV-1
  • Humans
  • Neutralization Tests
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Identity

PubMed Central ID

  • PMC2584972

International Standard Serial Number (ISSN)

  • 1078-8956

Digital Object Identifier (DOI)

  • 10.1038/nm1624

PubMed ID

  • 17721546
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Additional Document Info

start page

  • 1032

end page

  • 1034

volume

  • 13

issue

  • 9

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