Broad hiv-1 neutralization mediated by cd4-binding site antibodies

Academic Article

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Overview

authors

• Li, Yuxing
• Migueles, S. A.
• Welcher, B.
• Svehla, K.
• Phogat, A.
• Louder, M. K.
• Wu, X.
• Shaw, G. M.
• Connors, M.
• Wyatt, Richard
• Mascola, J. R.

publication date

• 2007

journal

• Nature Medicine  Journal

abstract

• We have identified several patient sera showing potent and broad HIV-1 neutralization. Using antibody adsorption and elution from selected gp120 variants, the neutralizing specificities of the two most broadly reactive sera were mapped to the primary receptor CD4-binding region of HIV-1 gp120. Novel antibodies to the CD4-binding site are elicited in some HIV-1-infected individuals, and new approaches to present this conserved region of gp120 to the immune system may result in improved vaccine immunogens.

subject areas

• Acquired Immunodeficiency Syndrome
• Antigens, CD
• Antigens, CD4
• Binding Sites, Antibody
• Cohort Studies
• HIV Antibodies
• HIV-1
• Humans
• Neutralization Tests

Identity

PubMed Central ID

• PMC2584972

International Standard Serial Number (ISSN)

• 1078-8956

Digital Object Identifier (DOI)

• 10.1038/nm1624

PubMed ID

• 17721546

Additional Document Info

start page

• 1032

end page

• 1034

volume

• 13

issue

• 9