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Cancer proteomics by quantitative shotgun proteomics

Academic Article
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Overview

authors

  • Chen, E. I.
  • Yates III, John

publication date

  • September 2007

journal

  • Molecular Oncology  Journal

abstract

  • A major scientific challenge at the present time for cancer research is the determination of the underlying biological basis for cancer development. It is further complicated by the heterogeneity of cancer's origin. Understanding the molecular basis of cancer requires studying the dynamic and spatial interactions among proteins in cells, signaling events among cancer cells, and interactions between the cancer cells and the tumor microenvironment. Recently, it has been proposed that large-scale protein expression analysis of cancer cell proteomes promises to be valuable for investigating mechanisms of cancer transformation. Advances in mass spectrometry technologies and bioinformatics tools provide a tremendous opportunity to qualitatively and quantitatively interrogate dynamic protein-protein interactions and differential regulation of cellular signaling pathways associated with tumor development. In this review, progress in shotgun proteomics technologies for examining the molecular basis of cancer development will be presented and discussed.

subject areas

  • Animals
  • Cell Transformation, Neoplastic
  • Computational Biology
  • Humans
  • Mass Spectrometry
  • Neoplasm Proteins
  • Neoplasms
  • Proteome
  • Proteomics
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Research

keywords

  • Cancer cells
  • Mass spectrometry
  • Protein profiling
  • Quantitative proteomics
  • Shotgun proteomics
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Identity

PubMed Central ID

  • PMC2352161

International Standard Serial Number (ISSN)

  • 1574-7891

Digital Object Identifier (DOI)

  • 10.1016/j.molonc.2007.05.001

PubMed ID

  • 18443658
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Additional Document Info

start page

  • 144

end page

  • 159

volume

  • 1

issue

  • 2

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