Scripps VIVO scripps research logo

  • Index
  • Log in
  • Home
  • People
  • Organizations
  • Research
  • Events
Search form

Retroviral induction of acute lymphoproliferative disease and profound immunosuppression in adult C57BL/6 mice

Academic Article
uri icon
  • Overview
  • Identity
  • Additional Document Info
  • View All
scroll to property group menus

Overview

authors

  • Mosier, Donald
  • Yetter, R. A.
  • Morse, H. C.

publication date

  • 1985

journal

  • Journal of Experimental Medicine  Journal

abstract

  • We have shown that a mixture of murine leukemia viruses (MuLV) causes the acute onset of lymphoproliferation and immunosuppression when injected into adult C57BL/6 mice. The ecotropic/MCF (mink cell focus-inducing) mixture of MuLV stimulates polyclonal B lymphocyte proliferation and differentiation to antibody-secreting cells. Serum Ig levels are elevated for all isotypes except IgA. The viral infection leads to a rapid decline in T lymphocyte responses to mitogens and alloantigens, as well as a decrease in helper cell activity. Specific antibody responses to both T-dependent and T-independent antigens are impaired, and the response of B lymphocytes to mitogens is abolished. The profound immunosuppression seems to be due to the MuLV-induced polyclonal activation of lymphocytes. No active suppression of normal lymphocyte responses by cells from virus-infected mice was observed. The disease induced by the LP-BM5 MuLV isolate thus seems a promising model for the study of lymphocyte activation and the mechanisms of retrovirus-induced immunosuppression.

subject areas

  • Acute Disease
  • Animals
  • B-Lymphocytes
  • Cell Transformation, Viral
  • Female
  • Hypergammaglobulinemia
  • Immune Tolerance
  • Leukemia Virus, Murine
  • Lymph Nodes
  • Lymphocyte Activation
  • Lymphoproliferative Disorders
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Phenotype
  • Spleen
  • T-Lymphocytes
  • Tumor Virus Infections
scroll to property group menus

Identity

PubMed Central ID

  • PMC2189053

International Standard Serial Number (ISSN)

  • 0022-1007

Digital Object Identifier (DOI)

  • 10.1084/jem.161.4.766

PubMed ID

  • 2984305
scroll to property group menus

Additional Document Info

start page

  • 766

end page

  • 784

volume

  • 161

issue

  • 4

©2021 The Scripps Research Institute | Terms of Use | Powered by VIVO

  • About
  • Contact Us
  • Support