recent publications

• academic article

  • Garcia, K. C., Degano, M., Stanfield, R. L., Brunmark, A., Jackson, M. R., Peterson, P. A., Teyton, L., Wilson, I. A. Pillars article: An alpha beta T cell receptor structure at 2.5 A and its orientation in the TCR-MHC complex (Science, 1996, 274:209-219) Journal of Immunology  2010 185:6402-6412  PMID:21084669
  • Landais, E., Romagnoli, P. A., Corper, A. L., Shires, J., Altman, J. D., Wilson, I. A., Garcia, K. C., Teyton, L. New design of MHC class II tetramers to accommodate fundamental principles of antigen presentation Journal of Immunology  2009 183:7949-7957  DOI:10.4049/jimmunol.0902493  PMID:19923463  PMCID:PMC2795019
  • Hanick, N. A., Rickert, M., Varani, L., Bankovich, A. J., Cochran, J. R., Kim, D. M., Surh, C. D., Garcia, K. C. Elucidation of the interleukin-15 binding site on its alpha receptor by NMR Biochemistry  2007 46:9453-9461  DOI:10.1021/bi700652f  PMID:17655329
  • Wucherpfennig, K. W., Allen, P. M., Celada, F., Cohen, I. R., De Boer, R., Garcia, K. C., Goldstein, B., Greenspan, R., Hafler, D., Hodgkin, P., Huseby, E. S., Krakauer, D. C., et al. Polyspecificity of t cell and b cell receptor recognition Seminars in Immunology  2007 19:216-224  DOI:10.1016/j.simm.2007.02.012  PMID:17398114
  • Sidobre, S., Naidenko, O. V., Sim, B. C., Gascoigne, N. R. J., Garcia, K. C., Kronenberg, M. The v alpha 14 nkt cell tcr exhibits high-affinity binding to a glycolipid/cd1d complex Journal of Immunology  2002 169:1340-1348  PMID:12133957
  • Corper, A. L., Stratmann, T., Apostolopoulos, V., Scott, C. A., Garcia, K. C., Kang, A. S., Wilson, I. A., Teyton, L. A structural framework for deciphering the link between I-A(g7) and autoimmune diabetes Science  2000 288:505-511  DOI:10.1126/science.288.5465.505  PMID:10775108
  • Degano, M., Garcia, K. C., Apostolopoulos, V., Rudolph, M. G., Teyton, L., Wilson, I. A. A functional hot spot for antigen recognition in a superagonist TCR/MHC complex Immunity  2000 12:251-261  DOI:10.1016/s1074-7613(00)80178-8  PMID:10755612
  • Garcia, K. C., Teyton, L., Wilson, L. A. Structural basis of T cell recognition Annual Review of Immunology  1999 17:369-397  DOI:10.1146/annurev.immunol.17.1.369  PMID:10358763
  • Cai, Z. L., Brunmark, A. B., Luxembourg, A. T., Garcia, K. C., Degano, M., Teyton, L., Wilson, I., Peterson, P. A., Sprent, J., Jackson, M. R. Probing the activation requirements for naive CD8(+) T cells with Drosophila cell transfectants as antigen presenting cells Immunological Reviews  1998 165:249-265  DOI:10.1111/j.1600-065X.1998.tb01243.x  PMID:9850865
  • Garcia, K. C., Teyton, L. T-cell receptor peptide-MHC interactions: biological lessons from structural studies Current Opinion in Biotechnology  1998 9:338-343  DOI:10.1016/s0958-1669(98)80004-9  PMID:9720260
  • Speir, J. A., Garcia, K. C., Brunmark, A., Degano, M., Peterson, P. A., Teyton, L., Wilson, I. A. Structural basis of 2C TCR allorecognition of H-2L(d) peptide complexes Immunity  1998 8:553-562  DOI:10.1016/s1074-7613(00)80560-9  PMID:9620676
  • Manning, T. C., Schlueter, C. J., Brodnicki, T. C., Parke, E. A., Speir, J. A., Garcia, K. C., Teyton, L., Wilson, I. A., Kranz, D. M. Alanine scanning mutagenesis of an alpha beta T cell receptor: mapping the energy of antigen recognition Immunity  1998 8:413-425  DOI:10.1016/s1074-7613(00)80547-6  PMID:9586632
  • Garcia, K. C., Degano, M., Pease, L. R., Huang, M. D., Peterson, P. A., Teyton, L., Wilson, I. A. Structural basis of plasticity in T cell receptor recognition of a self peptide-MHC antigen Science  1998 279:1166-1172  DOI:10.1126/science.279.5354.1166  PMID:9469799
  • Scott, C. A., Garcia, K. C., Stura, E. A., Peterson, P. A., Wilson, I. A., Teyton, L. Engineering protein for X-ray crystallography: the murine major histocompatibility complex class II molecule I-A(d) Protein Science  1998 7:413-418  DOI:10.1002/pro.5560070222  PMID:9521118  PMCID:PMC2143914
  • Garcia, K. C., Tallquist, M. D., Pease, L. R., Brunmark, A., Scott, C. A., Degano, M., Stura, E. A., Peterson, P. A., Wilson, I. A., Teyton, L. αβ T cell receptor interactions with syngeneic and allogeneic ligands: affinity measurements and crystallization Proceedings of the National Academy of Sciences of the United States of America  1997 94:13838-13843  DOI:10.1073/pnas.94.25.13838  PMID:9391114  PMCID:PMC28394
  • Wilson, I. A., Garcia, K. C. T-cell receptor structure and tcr complexes Current Opinion in Structural Biology  1997 7:839-848  DOI:10.1016/s0959-440x(97)80156-x  PMID:9434905
  • Garcia, K. C., Scott, C. A., Brunmark, A., Carbone, F. R., Peterson, P. A., Wilson, I. A., Teyton, L. CD8 enhances formation of stable T-cell receptor/MHC class I molecule complexes Nature  1996 384:577-581  DOI:10.1038/384577a0  PMID:8955273
  • Garcia, K. C., Degano, M., Stanfield, R. L., Brunmark, A., Jackson, M. R., Peterson, P. A., Teyton, L., Wilson, I. A. An alpha beta T cell receptor structure at 2.5 A and its orientation in the TCR-MHC complex Science  1996 274:209-219  DOI:10.1126/science.274.5285.209  PMID:8824178
  • Scott, C. A., Garcia, K. C., Carbone, F. R., Wilson, I. A., Teyton, L. Role of chain pairing for the production of functional soluble IA major histocompatibility complex class II molecules Journal of Experimental Medicine  1996 183:2087-2095  DOI:10.1084/jem.183.5.2087  PMID:8642319  PMCID:PMC2192579