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Fine mapping of an immunodominant domain in the transmembrane glycoprotein of human-immunodeficiency-virus

Academic Article
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Overview

authors

  • Gnann, J. W.
  • Nelson, J. A.
  • Oldstone, Michael

publication date

  • August 1987

journal

  • Journal of Virology  Journal

abstract

  • Sera from virtually all individuals infected with human immunodeficiency virus contain antibodies against the viral envelope glycoproteins. By using a series of synthetic peptide antigens, we identified an immunodominant domain at amino acid position 598-609 of gp41. The minimal essential epitope is a 7-amino-acid sequence (amino acids 603-609) containing two cysteine residues. Both cysteine residues are required for the antigenic conformation of the sequence, possibly due to creation of a cyclic structure via disulfide bond formation.

subject areas

  • Acquired Immunodeficiency Syndrome
  • Amino Acid Sequence
  • Antibodies, Viral
  • Antigens, Viral
  • Epitopes
  • Glycoproteins
  • HIV
  • Humans
  • Membrane Proteins
  • Peptide Fragments
  • Structure-Activity Relationship
  • Viral Proteins
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Identity

PubMed Central ID

  • PMC255715

International Standard Serial Number (ISSN)

  • 0022-538X

PubMed ID

  • 2439707
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Additional Document Info

start page

  • 2639

end page

  • 2641

volume

  • 61

issue

  • 8

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