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The effect of the phytoestrogen coumestrol on the nzb/w f1 murine model of systemic lupus

Academic Article
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Overview

authors

  • Schoenroth, L. J.
  • Hart, D. A.
  • Pollard, Kenneth Michael
  • Fritzler, M. J.

publication date

  • December 2004

journal

  • Journal of Autoimmunity  Journal

abstract

  • Coumestrol is a naturally occurring plant estrogen. As estrogen influences cellular and humoral immunity, and has known effects on murine models of lupus, we investigated the effect of coumestrol on disease expression in the NZB/W F1 mouse. Female NZB/W F1 mice were fed a "standard" rodent diet including soy proteins, a non-soy diet, or a non-soy diet with 0.01% coumestrol. Outcome measures included survival, autoantibody expression, immunoglobulin levels, proteinuria, renal histology and B cell immunohistochemistry, and renal mRNA expression. At 24 weeks, the treatment group had decreased prevalence of autoantibodies detected by immunofluorescence and less splenomegaly. At 39 weeks, the prevalence of autoantibodies was similar but the treatment group had less proteinuria. Overall, there was little effect of treatment on renal mRNA levels as assessed by gene array analysis, but functional ontology mapping revealed that genes encoding proteins involved in the immune response were most often affected. These results suggest that treatment with coumestrol may ameliorate some aspects of disease progression in this model of systemic autoimmunity.

subject areas

  • Animals
  • Antibody Formation
  • Autoantibodies
  • Autoimmunity
  • Chromatin
  • Coumestrol
  • Disease Models, Animal
  • Female
  • Gene Expression
  • Immunoglobulins
  • Kidney
  • Lupus Erythematosus, Systemic
  • Mice
  • Mice, Inbred NZB
  • Oligonucleotide Array Sequence Analysis
  • Phytoestrogens
  • RNA, Messenger
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Research

keywords

  • autoimmunity
  • coumestrol
  • phytoestrogen
  • systemic lupus
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Identity

International Standard Serial Number (ISSN)

  • 0896-8411

Digital Object Identifier (DOI)

  • 10.1016/j.taut.2004.09.004

PubMed ID

  • 15571926
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Additional Document Info

start page

  • 323

end page

  • 332

volume

  • 23

issue

  • 4

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