recent publications

• academic article

  • Popkin, D. L., Teijaro, J. R., Lee, A. M., Lewicki, H., Emonet, S., de la Torre, J. C., Oldstone, M. Expanded potential for recombinant trisegmented lymphocytic choriomeningitis viruses: Protein production, antibody production, and in vivo assessment of biological function of genes of interest Journal of Virology  2011 85:7928-7932  DOI:10.1128/jvi.00486-11  PMID:21613399  PMCID:PMC3147893
  • Ward, S. V., George, C. X., Welch, M. J., Liou, L. Y., Hahm, B., Lewicki, H., de la Torre, J. C., Samuel, C. E., Oldstone, M. B. RNA editing enzyme adenosine deaminase is a restriction factor for controlling measles virus replication that also is required for embryogenesis Proceedings of the National Academy of Sciences of the United States of America  2011 108:331-336  DOI:10.1073/pnas.1017241108  PMID:21173229  PMCID:PMC3017198
  • Homann, D., Lewicki, H., Brooks, D., Eberlein, J., Mallet-Designe, V., Teyton, L., Oldstone, M. B. A. Mapping and restriction of a dominant viral CD4(+) T cell core epitope by both MHC class I and MHC class II Virology  2007 363:113-123  DOI:10.1016/j.virol.2006.12.025  PMID:17320138  PMCID:PMC1976554
  • Tishon, A., Lewicki, H., Andaya, A., McGavern, D., Martin, L., Oldstone, M. B. A. Cd4 t cell control primary measles virus infection of the cns: Regulation is dependent on combined activity with either cd8 t cells or with b cells: Cd4, cd8 or b cells alone are ineffective Virology  2006 347:234-245  DOI:10.1016/j.virol.2006.01.050  PMID:16529787
  • Go, E. P., Wikoff, W. R., Shen, Z. X., O'Maille, G., Morita, H., Conrads, T. P., Nordstrom, A., Trauger, S. A., Uritboonthai, W., Lucas, D. A., Chan, K. C., Veenstra, T. D., et al. Mass spectrometry reveals specific and global molecular transformations during viral infection Journal of Proteome Research  2006 5:2405-2416  DOI:10.1021/pr060215t  PMID:16944953  PMCID:PMC2566936
  • Oldstone, M. B. A., Dales, S., Tishon, A., Lewicki, H., Martin, L. A role for dual viral hits in causation of subacute sclerosing panencephalitis Journal of Experimental Medicine  2005 202:1185-1190  DOI:10.1084/jem.20051376  PMID:16260490  PMCID:PMC1350947
  • Lewicki, H., Tishon, A., Homann, D., Mazarguil, H., Laval, F., Asensio, V. C., Campbell, I. L., DeArmond, S., Coon, B., Teng, C., Gairin, J. E., Oldstone, M. B. A. T cells infiltrate the brain in murine and human transmissible spongiform encephalopathies Journal of Virology  2003 77:3799-3808  DOI:10.1128/jvi.77.6.3799-3808.2003  PMID:12610154
  • Oldstone, M. B. A., Race, R., Thomas, D., Lewicki, H., Homann, D., Smelt, S., Holz, A., Koni, P., Lo, D., Chesebro, B., Flavell, R. Lymphotoxin-alpha- and lymphotoxin-beta-deficient mice differ in susceptibility to scrapie: Evidence against dendritic cell involvement in neuroinvasion Journal of Virology  2002 76:4357-4363  DOI:10.1128/jvi.76.9.4357-4363.2002  PMID:11932402
  • Oldstone, M. B. A., Homann, D., Lewicki, H., Stevenson, D. One, two, or three step: Measles virus receptor dance Virology  2002 299:162-163  DOI:10.1006/viro.2002.1507  PMID:12202218
  • Oldstone, M. B. A., Lewicki, H., Homann, D., Nguyen, C., Julien, S., Gairin, J. E. Common antiviral cytotoxic t-lymphocyte epitope for diverse arenaviruses Journal of Virology  2001 75:6273-6278  DOI:10.1128/jvi.75.14.6273-6278.2001  PMID:11413293
  • Smelt, S. C., Borrow, P., Kunz, S., Cao, W., Tishon, A., Lewicki, H., Campbell, K. P., Oldstone, M. B. A. Differences in affinity of binding of lymphocytic choriomeningitis virus strains to the cellular receptor alpha-dystroglycan correlate with viral tropism and disease kinetics Journal of Virology  2001 75:448-457  DOI:10.1128/jvi.75.1.448-457.2001  PMID:11119613
  • Patterson, J. B., Cornu, T. I., Redwine, J., Dales, S., Lewicki, H., Holz, A., Thomas, D., Billeter, M. A., Oldstone, M. B. A. Evidence that the hypermutated m protein of a subacute sclerosing panencephalitis measles virus actively contributes to the chronic progressive cns disease Virology  2001 291:215-225  DOI:10.1006/viro.2001.1182  PMID:11878891
  • Hudrisier, D., Riond, J., Burlet-Schiltz, O., von Herrath, M. G., Lewicki, H., Monsarrat, B., Oldstone, M. B. A., Gairin, J. E. Structural and functional identification of major histocompatibility complex class i-restricted self-peptides as naturally occurring molecular mimics of viral antigens - possible role in cd8(+) t cell-mediated, virus-induced autoimmune disease Journal of Biological Chemistry  2001 276:19396-19403  DOI:10.1074/jbc.M008864200  PMID:11278441
  • Sevilla, N., Kunz, S., Holz, A., Lewicki, H., Homann, D., Yamada, H., Campbell, K. P., de la Torre, J. C., Oldstone, M. B. A. Immunosuppression and resultant viral persistence by specific viral targeting of dendritic cells Journal of Experimental Medicine  2000 192:1249-1260  DOI:10.1084/jem.192.9.1249  PMID:11067874
  • Tishon, A., LaFace, D. M., Lewicki, H., van Binnendijk, R. S., Osterhaus, A., Oldstone, M. B. A. Transgenic mice expressing human hla and cd8 molecules generate hla-restricted measles virus cytotoxic t lymphocytes of the same specificity as humans with natural measles virus infection Virology  2000 275:286-293  DOI:10.1006/viro.2000.0517  PMID:10998329
  • Patterson, J. B., Thomas, D., Lewicki, H., Billeter, M. A., Oldstone, M. B. A. V and c proteins of measles virus function as virulence factors in vivo Virology  2000 267:80-89  DOI:10.1006/viro.1999.0118  PMID:10648185
  • Oldstone, M. B. A., Lewicki, H., Thomas, D., Tishon, A., Dales, S., Patterson, J., Manchester, M., Homann, D., Naniche, D., Holz, A. Measles virus infection in a transgenic model: Virus-induced immunosuppression and central nervous system disease Cell  1999 98:629-640  DOI:10.1016/s0092-8674(00)80050-1  PMID:10490102
  • Oldstone, M. B. A., von Herrath, M., Lewicki, H., Hudrisier, D., Whitton, J. L., Gairin, J. E. Use of a high-affinity peptide that aborts mhc-restricted cytotoxic t lymphocyte activity against multiple viruses in vitro and virus-induced immunopathologic disease in vivo Virology  1999 256:246-257  DOI:10.1006/viro.1998.9593  PMID:10191190
  • von Herrath, M. G., Coon, B., Lewicki, H., Mazarguil, H., Gairin, J. E., Oldstone, M. B. A. In vivo treatment with a mhc class i-restricted blocking peptide can prevent virus-induced autoimmune diabetes Journal of Immunology  1998 161:5087-5096  PMID:9794447
  • Borrow, P., Lewicki, H., Wei, X. P., Horwitz, M. S., Peffer, N., Meyers, H., Nelson, J. A., Gairin, J. E., Hahn, B. H., Oldstone, M. B. A., Shaw, G. M. Antiviral pressure exerted by hiv-1-specific cytotoxic t lymphocytes (ctls) during primary infection demonstrated by rapid selection of ctl escape virus Nature Medicine  1997 3:205-211  DOI:10.1038/nm0297-205  PMID:9018240
  • Tishon, A., Lewicki, H., Rall, G., Vonherrath, M., Oldstone, M. B. A. An essential role for type-1 interferon-gamma in terminating persistent viral-infection Virology  1995 212:244-250  DOI:10.1006/viro.1995.1477  PMID:7676639
  • von Herrath, M. G., Guerder, S., Lewicki, H., Flavell, R. A., Oldstone, M. B. A. Coexpression of b7-1 and viral (''self'') transgenes in pancreatic beta cells can break peripheral ignorance and lead to spontaneous autoimmune diabetes Immunity  1995 3:727-738  DOI:10.1016/1074-7613(95)90062-4  PMID:8777718
  • Lewicki, H., Tishon, A., Borrow, P., Evans, C. F., Gairin, J. E., Hahn, K. M., Jewell, D. A., Wilson, I. A., Oldstone, M. B. A. Ctl escape viral variants .1. Generation and molecular characterization Virology  1995 210:29-40  DOI:10.1006/viro.1995.1314  PMID:7793078
  • Oldstone, M. B. A., Lewicki, H., Borrow, P., Hudrisier, D., Gairin, J. E. Discriminated selection among viral peptides with the appropriate anchor residues - implications for the size of the cytotoxic t-lymphocyte repertoire and control of viral-infection Journal of Virology  1995 69:7423-7429  PMID:7494247  PMCID:PMC189679
  • Hahn, K., Debiasio, R., Tishon, A., Lewicki, H., Gairin, J. E., Larocca, G., Taylor, D. L., Oldstone, M. Antigen presentation and cytotoxic t-lymphocyte killing studied in individual, living cells Virology  1994 201:330-340  DOI:10.1006/viro.1994.1298  PMID:8184542
  • Borrow, P., Lewicki, H., Hahn, B. H., Shaw, G. M., Oldstone, M. B. A. Virus-specific cd8+ cytotoxic t-lymphocyte activity associated with control of viremia in primary human-immunodeficiency-virus type-1 infection Journal of Virology  1994 68:6103-6110  PMID:8057491  PMCID:PMC237022
  • Oldstone, M. B. A., Tishon, A., Geckeler, R., Lewicki, H., Whitton, J. L. A common antiviral cytotoxic lymphocyte-t epitope for diverse major histocompatibility complex haplotypes - implications for vaccination Proceedings of the National Academy of Sciences of the United States of America  1992 89:2752-2755  DOI:10.1073/pnas.89.7.2752  PMID:1372990
  • Yanagi, Y., Tishon, A., Lewicki, H., Cubitt, B. A., Oldstone, M. B. A. Diversity of T-cell receptors in virus-specific cytotoxic T lymphocytes recognizing three distinct viral epitopes restricted by a single major histocompatibility complex molecule Journal of Virology  1992 66:2527-2531  PMID:1372370  PMCID:PMC289052
  • Lewicki, H., McKee, T. A., Tishon, A., Salvato, M., Whitton, J. L., Oldstone, M. B. A. Novel lcmv-specific h-2k restricted ctl clones recognize internal viral gene-products and cause cns disease Journal of Neuroimmunology  1992 41:15-20  DOI:10.1016/0165-5728(92)90190-v  PMID:1281166
  • Oldstone, M. B. A., Tishon, A., Lewicki, H., Dyson, H. J., Feher, V. A., Assamunt, N., Wright, P. E. Mapping the anatomy of the immunodominant domain of the human immunodeficiency virus gp41 transmembrane protein: peptide conformation analysis using monoclonal antibodies and proton nuclear magnetic resonance spectroscopy Journal of Virology  1991 65:1727-1734  PMID:2002540  PMCID:PMC239977
  • Oldstone, M. B. A., Nerenberg, M., Southern, P., Price, J., Lewicki, H. Virus-infection triggers insulin-dependent diabetes-mellitus in a transgenic model - role of anti-self (virus) immune-response Cell  1991 65:319-331  DOI:10.1016/0092-8674(91)90165-u  PMID:1901765
  • Oldstone, M. B. A., Tishon, A., Schwimmbeck, P. L., Shyp, S., Lewicki, H., Dyrberg, T. Cytotoxic lymphocytes-t do not control lymphocytic choriomeningitis virus-infection of bb diabetes-prone rats Journal of General Virology  1990 71:785-791  DOI:10.1099/0022-1317-71-4-785  PMID:2324708
  • Whitton, J. L., Tishon, A., Lewicki, H., Gebhard, J., Cook, T., Salvato, M., Joly, E., Oldstone, M. B. A. Molecular analyses of a 5-amino-acid cyto-toxic lymphocyte-t (ctl) epitope - an immunodominant region which induces nonreciprocal ctl cross-reactivity Journal of Virology  1989 63:4303-4310  PMID:2476570  PMCID:PMC251046
  • Oldstone, M. B. A., Whitton, J. L., Lewicki, H., Tishon, A. Fine dissection of a 9 amino-acid glycoprotein epitope, a major determinant recognized by lymphocytic choriomeningitis virus-specific class-i-restricted h-2db cyto-toxic lymphocytes-t Journal of Experimental Medicine  1988 168:559-570  DOI:10.1084/jem.168.2.559  PMID:2457647
  • Whitton, J. L., Gebhard, J. R., Lewicki, H., Tishon, A., Oldstone, M. B. A. Molecular definition of a major cyto-toxic lymphocyte-t epitope in the glycoprotein of lymphocytic choriomeningitis virus Journal of Virology  1988 62:687-695  PMID:2448497  PMCID:PMC253621
  • Oldstone, M. B. A., Salvato, M., Tishon, A., Lewicki, H. Virus lymphocyte interactions .3. Biologic parameters of a virus variant that fails to generate ctl and establishes persistent infection in immunocompetent hosts Virology  1988 164:507-516  DOI:10.1016/0042-6822(88)90565-x  PMID:2967012