recent publications
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academic article
- Popkin, D. L., Teijaro, J. R., Lee, A. M., Lewicki, H., Emonet, S., de la Torre, J. C., Oldstone, M. Expanded potential for recombinant trisegmented lymphocytic choriomeningitis viruses: Protein production, antibody production, and in vivo assessment of biological function of genes of interest Journal of Virology 2011 85:7928-7932 DOI:10.1128/jvi.00486-11 PMID:21613399 PMCID:PMC3147893
- Ward, S. V., George, C. X., Welch, M. J., Liou, L. Y., Hahm, B., Lewicki, H., de la Torre, J. C., Samuel, C. E., Oldstone, M. B. RNA editing enzyme adenosine deaminase is a restriction factor for controlling measles virus replication that also is required for embryogenesis Proceedings of the National Academy of Sciences of the United States of America 2011 108:331-336 DOI:10.1073/pnas.1017241108 PMID:21173229 PMCID:PMC3017198
- Homann, D., Lewicki, H., Brooks, D., Eberlein, J., Mallet-Designe, V., Teyton, L., Oldstone, M. B. A. Mapping and restriction of a dominant viral CD4(+) T cell core epitope by both MHC class I and MHC class II Virology 2007 363:113-123 DOI:10.1016/j.virol.2006.12.025 PMID:17320138 PMCID:PMC1976554
- Go, E. P., Wikoff, W. R., Shen, Z. X., O'Maille, G., Morita, H., Conrads, T. P., Nordstrom, A., Trauger, S. A., Uritboonthai, W., Lucas, D. A., Chan, K. C., Veenstra, T. D., et al. Mass spectrometry reveals specific and global molecular transformations during viral infection Journal of Proteome Research 2006 5:2405-2416 DOI:10.1021/pr060215t PMID:16944953 PMCID:PMC2566936
- Tishon, A., Lewicki, H., Andaya, A., McGavern, D., Martin, L., Oldstone, M. B. A. Cd4 t cell control primary measles virus infection of the cns: Regulation is dependent on combined activity with either cd8 t cells or with b cells: Cd4, cd8 or b cells alone are ineffective Virology 2006 347:234-245 DOI:10.1016/j.virol.2006.01.050 PMID:16529787
- Oldstone, M. B. A., Dales, S., Tishon, A., Lewicki, H., Martin, L. A role for dual viral hits in causation of subacute sclerosing panencephalitis Journal of Experimental Medicine 2005 202:1185-1190 DOI:10.1084/jem.20051376 PMID:16260490 PMCID:PMC1350947
- Lewicki, H., Tishon, A., Homann, D., Mazarguil, H., Laval, F., Asensio, V. C., Campbell, I. L., DeArmond, S., Coon, B., Teng, C., Gairin, J. E., Oldstone, M. B. A. T cells infiltrate the brain in murine and human transmissible spongiform encephalopathies Journal of Virology 2003 77:3799-3808 DOI:10.1128/jvi.77.6.3799-3808.2003 PMID:12610154
- Oldstone, M. B. A., Homann, D., Lewicki, H., Stevenson, D. One, two, or three step: Measles virus receptor dance Virology 2002 299:162-163 DOI:10.1006/viro.2002.1507 PMID:12202218
- Oldstone, M. B. A., Race, R., Thomas, D., Lewicki, H., Homann, D., Smelt, S., Holz, A., Koni, P., Lo, D., Chesebro, B., Flavell, R. Lymphotoxin-alpha- and lymphotoxin-beta-deficient mice differ in susceptibility to scrapie: Evidence against dendritic cell involvement in neuroinvasion Journal of Virology 2002 76:4357-4363 DOI:10.1128/jvi.76.9.4357-4363.2002 PMID:11932402
- Patterson, J. B., Cornu, T. I., Redwine, J., Dales, S., Lewicki, H., Holz, A., Thomas, D., Billeter, M. A., Oldstone, M. B. A. Evidence that the hypermutated m protein of a subacute sclerosing panencephalitis measles virus actively contributes to the chronic progressive cns disease Virology 2001 291:215-225 DOI:10.1006/viro.2001.1182 PMID:11878891
- Oldstone, M. B. A., Lewicki, H., Homann, D., Nguyen, C., Julien, S., Gairin, J. E. Common antiviral cytotoxic t-lymphocyte epitope for diverse arenaviruses Journal of Virology 2001 75:6273-6278 DOI:10.1128/jvi.75.14.6273-6278.2001 PMID:11413293
- Hudrisier, D., Riond, J., Burlet-Schiltz, O., von Herrath, M. G., Lewicki, H., Monsarrat, B., Oldstone, M. B. A., Gairin, J. E. Structural and functional identification of major histocompatibility complex class i-restricted self-peptides as naturally occurring molecular mimics of viral antigens - possible role in cd8(+) t cell-mediated, virus-induced autoimmune disease Journal of Biological Chemistry 2001 276:19396-19403 DOI:10.1074/jbc.M008864200 PMID:11278441
- Smelt, S. C., Borrow, P., Kunz, S., Cao, W., Tishon, A., Lewicki, H., Campbell, K. P., Oldstone, M. B. A. Differences in affinity of binding of lymphocytic choriomeningitis virus strains to the cellular receptor alpha-dystroglycan correlate with viral tropism and disease kinetics Journal of Virology 2001 75:448-457 DOI:10.1128/jvi.75.1.448-457.2001 PMID:11119613
- Sevilla, N., Kunz, S., Holz, A., Lewicki, H., Homann, D., Yamada, H., Campbell, K. P., de la Torre, J. C., Oldstone, M. B. A. Immunosuppression and resultant viral persistence by specific viral targeting of dendritic cells Journal of Experimental Medicine 2000 192:1249-1260 DOI:10.1084/jem.192.9.1249 PMID:11067874
- Tishon, A., LaFace, D. M., Lewicki, H., van Binnendijk, R. S., Osterhaus, A., Oldstone, M. B. A. Transgenic mice expressing human hla and cd8 molecules generate hla-restricted measles virus cytotoxic t lymphocytes of the same specificity as humans with natural measles virus infection Virology 2000 275:286-293 DOI:10.1006/viro.2000.0517 PMID:10998329
- Patterson, J. B., Thomas, D., Lewicki, H., Billeter, M. A., Oldstone, M. B. A. V and c proteins of measles virus function as virulence factors in vivo Virology 2000 267:80-89 DOI:10.1006/viro.1999.0118 PMID:10648185
- Oldstone, M. B. A., Lewicki, H., Thomas, D., Tishon, A., Dales, S., Patterson, J., Manchester, M., Homann, D., Naniche, D., Holz, A. Measles virus infection in a transgenic model: Virus-induced immunosuppression and central nervous system disease Cell 1999 98:629-640 DOI:10.1016/s0092-8674(00)80050-1 PMID:10490102
- Oldstone, M. B. A., von Herrath, M., Lewicki, H., Hudrisier, D., Whitton, J. L., Gairin, J. E. Use of a high-affinity peptide that aborts mhc-restricted cytotoxic t lymphocyte activity against multiple viruses in vitro and virus-induced immunopathologic disease in vivo Virology 1999 256:246-257 DOI:10.1006/viro.1998.9593 PMID:10191190
- von Herrath, M. G., Coon, B., Lewicki, H., Mazarguil, H., Gairin, J. E., Oldstone, M. B. A. In vivo treatment with a mhc class i-restricted blocking peptide can prevent virus-induced autoimmune diabetes Journal of Immunology 1998 161:5087-5096 PMID:9794447
- Borrow, P., Lewicki, H., Wei, X. P., Horwitz, M. S., Peffer, N., Meyers, H., Nelson, J. A., Gairin, J. E., Hahn, B. H., Oldstone, M. B. A., Shaw, G. M. Antiviral pressure exerted by hiv-1-specific cytotoxic t lymphocytes (ctls) during primary infection demonstrated by rapid selection of ctl escape virus Nature Medicine 1997 3:205-211 DOI:10.1038/nm0297-205 PMID:9018240
- Oldstone, M. B. A., Lewicki, H., Borrow, P., Hudrisier, D., Gairin, J. E. Discriminated selection among viral peptides with the appropriate anchor residues - implications for the size of the cytotoxic t-lymphocyte repertoire and control of viral-infection Journal of Virology 1995 69:7423-7429 PMID:7494247 PMCID:PMC189679
- Tishon, A., Lewicki, H., Rall, G., Vonherrath, M., Oldstone, M. B. A. An essential role for type-1 interferon-gamma in terminating persistent viral-infection Virology 1995 212:244-250 DOI:10.1006/viro.1995.1477 PMID:7676639
- Lewicki, H., Tishon, A., Borrow, P., Evans, C. F., Gairin, J. E., Hahn, K. M., Jewell, D. A., Wilson, I. A., Oldstone, M. B. A. Ctl escape viral variants .1. Generation and molecular characterization Virology 1995 210:29-40 DOI:10.1006/viro.1995.1314 PMID:7793078
- von Herrath, M. G., Guerder, S., Lewicki, H., Flavell, R. A., Oldstone, M. B. A. Coexpression of b7-1 and viral (''self'') transgenes in pancreatic beta cells can break peripheral ignorance and lead to spontaneous autoimmune diabetes Immunity 1995 3:727-738 DOI:10.1016/1074-7613(95)90062-4 PMID:8777718
- Borrow, P., Lewicki, H., Hahn, B. H., Shaw, G. M., Oldstone, M. B. A. Virus-specific cd8+ cytotoxic t-lymphocyte activity associated with control of viremia in primary human-immunodeficiency-virus type-1 infection Journal of Virology 1994 68:6103-6110 PMID:8057491 PMCID:PMC237022
- Hahn, K., Debiasio, R., Tishon, A., Lewicki, H., Gairin, J. E., Larocca, G., Taylor, D. L., Oldstone, M. Antigen presentation and cytotoxic t-lymphocyte killing studied in individual, living cells Virology 1994 201:330-340 DOI:10.1006/viro.1994.1298 PMID:8184542
- Lewicki, H., McKee, T. A., Tishon, A., Salvato, M., Whitton, J. L., Oldstone, M. B. A. Novel lcmv-specific h-2k restricted ctl clones recognize internal viral gene-products and cause cns disease Journal of Neuroimmunology 1992 41:15-20 DOI:10.1016/0165-5728(92)90190-v PMID:1281166
- Oldstone, M. B. A., Tishon, A., Geckeler, R., Lewicki, H., Whitton, J. L. A common antiviral cytotoxic lymphocyte-t epitope for diverse major histocompatibility complex haplotypes - implications for vaccination Proceedings of the National Academy of Sciences of the United States of America 1992 89:2752-2755 DOI:10.1073/pnas.89.7.2752 PMID:1372990
- Yanagi, Y., Tishon, A., Lewicki, H., Cubitt, B. A., Oldstone, M. B. A. Diversity of T-cell receptors in virus-specific cytotoxic T lymphocytes recognizing three distinct viral epitopes restricted by a single major histocompatibility complex molecule Journal of Virology 1992 66:2527-2531 PMID:1372370 PMCID:PMC289052
- Oldstone, M. B. A., Nerenberg, M., Southern, P., Price, J., Lewicki, H. Virus-infection triggers insulin-dependent diabetes-mellitus in a transgenic model - role of anti-self (virus) immune-response Cell 1991 65:319-331 DOI:10.1016/0092-8674(91)90165-u PMID:1901765
- Oldstone, M. B. A., Tishon, A., Lewicki, H., Dyson, H. J., Feher, V. A., Assamunt, N., Wright, P. E. Mapping the anatomy of the immunodominant domain of the human immunodeficiency virus gp41 transmembrane protein: peptide conformation analysis using monoclonal antibodies and proton nuclear magnetic resonance spectroscopy Journal of Virology 1991 65:1727-1734 PMID:2002540 PMCID:PMC239977
- Oldstone, M. B. A., Tishon, A., Schwimmbeck, P. L., Shyp, S., Lewicki, H., Dyrberg, T. Cytotoxic lymphocytes-t do not control lymphocytic choriomeningitis virus-infection of bb diabetes-prone rats Journal of General Virology 1990 71:785-791 DOI:10.1099/0022-1317-71-4-785 PMID:2324708
- Whitton, J. L., Tishon, A., Lewicki, H., Gebhard, J., Cook, T., Salvato, M., Joly, E., Oldstone, M. B. A. Molecular analyses of a 5-amino-acid cyto-toxic lymphocyte-t (ctl) epitope - an immunodominant region which induces nonreciprocal ctl cross-reactivity Journal of Virology 1989 63:4303-4310 PMID:2476570 PMCID:PMC251046
- Oldstone, M. B. A., Whitton, J. L., Lewicki, H., Tishon, A. Fine dissection of a 9 amino-acid glycoprotein epitope, a major determinant recognized by lymphocytic choriomeningitis virus-specific class-i-restricted h-2db cyto-toxic lymphocytes-t Journal of Experimental Medicine 1988 168:559-570 DOI:10.1084/jem.168.2.559 PMID:2457647
- Oldstone, M. B. A., Salvato, M., Tishon, A., Lewicki, H. Virus lymphocyte interactions .3. Biologic parameters of a virus variant that fails to generate ctl and establishes persistent infection in immunocompetent hosts Virology 1988 164:507-516 DOI:10.1016/0042-6822(88)90565-x PMID:2967012
- Whitton, J. L., Gebhard, J. R., Lewicki, H., Tishon, A., Oldstone, M. B. A. Molecular definition of a major cyto-toxic lymphocyte-t epitope in the glycoprotein of lymphocytic choriomeningitis virus Journal of Virology 1988 62:687-695 PMID:2448497 PMCID:PMC253621