recent publications

• academic article

  • Musille, P. M., Pathak, M., Lauer, J. L., Griffin, P. R., Ortlund, E. A. Divergent sequence tunes ligand sensitivity in phospholipid-regulated hormone receptors Journal of Biological Chemistry  2013 288:20702-20712  DOI:10.1074/jbc.M113.472837  PMID:23737522  PMCID:PMC3711333
  • Pascal, B. D., Willis, S., Lauer, J. L., Landgraf, R. R., West, G. M., Marciano, D., Novick, S., Goswami, D., Chalmers, M. J., Griffin, P. R. HDX workbench: software for the analysis of H/D exchange MS data Journal of the American Society for Mass Spectrometry  2012 23:1512-1521  DOI:10.1007/s13361-012-0419-6  PMID:22692830  PMCID:PMC3808162
  • Musille, P. M., Pathak, M. C., Lauer, J. L., Hudson, W. H., Griffin, P. R., Ortlund, E. A. Antidiabetic phospholipid-nuclear receptor complex reveals the mechanism for phospholipid-driven gene regulation Nature Structural & Molecular Biology  2012 19:532-7, S1  DOI:10.1038/nsmb.2279  PMID:22504882  PMCID:PMC3960984
  • Kumar, N., Lyda, B., Chang, M. R., Lauer, J. L., Solt, L. A., Burris, T. P., Kamenecka, T. M., Griffin, P. R. Identification of SR2211: a potent synthetic ROR gamma-selective modulator ACS Chemical Biology  2012 7:672-677  DOI:10.1021/cb200496y  PMID:22292739  PMCID:PMC3331898
  • Solt, L. A., Kumar, N., Nuhant, P., Wang, Y. J., Lauer, J. L., Liu, J., Istrate, M. A., Kamenecka, T. M., Roush, W. R., Vidovic, D., Schurer, S. C., Xu, J. H., et al. Suppression of TH17 differentiation and autoimmunity by a synthetic ROR ligand Nature  2011 472:491-494  DOI:10.1038/nature10075  PMID:21499262  PMCID:PMC3148894