recent publications

• academic article

  • Beutler, E., Van Geet, C., te Loo, Dmwm, Gelbart, T., Crain, K., Truksa, J., Lee, P. L. Polymorphisms and mutations of human tmprss6 in iron deficiency anemia Blood Cells Molecules and Diseases  2010 44:16-21  DOI:10.1016/j.bcmd.2009.09.001  PMID:19818657  PMCID:PMC2818284
  • Truksa, J., Gelbart, T., Peng, H. F., Beutler, E., Beutler, B., Lee, P. Suppression of the hepcidin-encoding gene hamp permits iron overload in mice lacking both hemojuvelin and matriptase-2/tmprss6 British Journal of Haematology  2009 147:571-581  DOI:10.1111/j.1365-2141.2009.07873.x  PMID:19751239
  • Truksa, J., Lee, P., Beutler, E. Two bmp responsive elements, stat, and bzip/hnf4/coup motifs of the hepcidin promoter are critical for bmp, smad1, and hjv responsiveness Blood  2009 113:688-695  DOI:10.1182/blood-2008-05-160184  PMID:18997172  PMCID:PMC2628375
  • Du, X., She, E., Gelbart, T., Truksa, J., Lee, P., Xia, Y., Khovananth, K., Mudd, S., Mann, N., Moresco, E. M. Y., Beutler, E., Beutler, B. The serine protease tmprss6 is required to sense iron deficiency Science  2008 320:1088-1092  DOI:10.1126/science.1157121  PMID:18451267  PMCID:PMC2430097
  • Truksa, J., Lee, P., Peng, H. F., Flanagan, J., Beutler, E. The distal location of the iron responsive region of the hepcidin promoter Blood  2007 110:3436-3437  DOI:10.1182/blood-2007-05-091108  PMID:17644736  PMCID:PMC2200907
  • Truksa, J., Lee, P., Beutler, E. The role of stat, ap-1, e-box and tieg motifs in the regulation of hepcidin by il-6 and bmp-9: Lessons from human hamp and murine hamp1 and hamp2 gene promoters Blood Cells Molecules and Diseases  2007 39:255-262  DOI:10.1016/j.bcmd.2007.06.014  PMID:17689119  PMCID:PMC2743926
  • Truksa, J., Peng, H. F., Lee, P., Beutler, E. Different regulatory elements are required for response of hepcidin to interleukin-6 and bone morphogenetic proteins 4 and 9 British Journal of Haematology  2007 139:138-147  DOI:10.1111/j.1365-2141.2007.06728.x  PMID:17854319
  • Flanagan, J. M., Truksa, J., Peng, H. F., Lee, P., Beutler, E. In vivo imaging of hepcidin promoter stimulation by iron and inflammation Blood Cells Molecules and Diseases  2007 38:253-257  DOI:10.1016/j.bcmd.2007.01.004  PMID:17331760  PMCID:PMC1924465
  • Truksa, J., Peng, H. F., Lee, P., Beutler, E. Bone morphogenetic proteins 2, 4, and 9 stimulate murine hepcidin 1 expression independently of hfe, transferrin receptor 2 (tfr2), and il-6 Proceedings of the National Academy of Sciences of the United States of America  2006 103:10289-10293  DOI:10.1073/pnas.0603124103  PMID:16801541  PMCID:PMC1502450