recent publications
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academic article
- Beutler, E., Van Geet, C., te Loo, Dmwm, Gelbart, T., Crain, K., Truksa, J., Lee, P. L. Polymorphisms and mutations of human tmprss6 in iron deficiency anemia Blood Cells Molecules and Diseases 2010 44:16-21 DOI:10.1016/j.bcmd.2009.09.001 PMID:19818657 PMCID:PMC2818284
- Truksa, J., Gelbart, T., Peng, H. F., Beutler, E., Beutler, B., Lee, P. Suppression of the hepcidin-encoding gene hamp permits iron overload in mice lacking both hemojuvelin and matriptase-2/tmprss6 British Journal of Haematology 2009 147:571-581 DOI:10.1111/j.1365-2141.2009.07873.x PMID:19751239
- Truksa, J., Lee, P., Beutler, E. Two bmp responsive elements, stat, and bzip/hnf4/coup motifs of the hepcidin promoter are critical for bmp, smad1, and hjv responsiveness Blood 2009 113:688-695 DOI:10.1182/blood-2008-05-160184 PMID:18997172 PMCID:PMC2628375
- Du, X., She, E., Gelbart, T., Truksa, J., Lee, P., Xia, Y., Khovananth, K., Mudd, S., Mann, N., Moresco, E. M. Y., Beutler, E., Beutler, B. The serine protease tmprss6 is required to sense iron deficiency Science 2008 320:1088-1092 DOI:10.1126/science.1157121 PMID:18451267 PMCID:PMC2430097
- Truksa, J., Lee, P., Peng, H. F., Flanagan, J., Beutler, E. The distal location of the iron responsive region of the hepcidin promoter Blood 2007 110:3436-3437 DOI:10.1182/blood-2007-05-091108 PMID:17644736 PMCID:PMC2200907
- Truksa, J., Lee, P., Beutler, E. The role of stat, ap-1, e-box and tieg motifs in the regulation of hepcidin by il-6 and bmp-9: Lessons from human hamp and murine hamp1 and hamp2 gene promoters Blood Cells Molecules and Diseases 2007 39:255-262 DOI:10.1016/j.bcmd.2007.06.014 PMID:17689119 PMCID:PMC2743926
- Truksa, J., Peng, H. F., Lee, P., Beutler, E. Different regulatory elements are required for response of hepcidin to interleukin-6 and bone morphogenetic proteins 4 and 9 British Journal of Haematology 2007 139:138-147 DOI:10.1111/j.1365-2141.2007.06728.x PMID:17854319
- Flanagan, J. M., Truksa, J., Peng, H. F., Lee, P., Beutler, E. In vivo imaging of hepcidin promoter stimulation by iron and inflammation Blood Cells Molecules and Diseases 2007 38:253-257 DOI:10.1016/j.bcmd.2007.01.004 PMID:17331760 PMCID:PMC1924465
- Truksa, J., Peng, H. F., Lee, P., Beutler, E. Bone morphogenetic proteins 2, 4, and 9 stimulate murine hepcidin 1 expression independently of hfe, transferrin receptor 2 (tfr2), and il-6 Proceedings of the National Academy of Sciences of the United States of America 2006 103:10289-10293 DOI:10.1073/pnas.0603124103 PMID:16801541 PMCID:PMC1502450