recent publications

• academic article

  • Wang, Y., Zhao, Z., Chow, N., Rajput, P. S., Griffin, J. H., Lyden, P. D., Zlokovic, B. V. Activated protein C analog protects from ischemic stroke and extends the therapeutic window of tissue-type plasminogen activator in aged female mice and hypertensive rats Stroke  2013 44:3529-3536  DOI:10.1161/strokeaha.113.003350  PMID:24159062
  • Wang, Y., Zhao, Z., Chow, N., Ali, T., Griffin, J. H., Zlokovic, B. V. Activated protein C analog promotes neurogenesis and improves neurological outcome after focal ischemic stroke in mice via protease activated receptor 1 Brain Research  2013 1507:97-104  DOI:10.1016/j.brainres.2013.02.023  PMID:23438513  PMCID:PMC3739836
  • Guo, H., Zhao, Z., Yang, Q., Wang, M., Bell, R. D., Wang, S., Chow, N., Davis, T. P., Griffin, J. H., Goldman, S. A., Zlokovic, B. V. An activated protein C analog stimulates neuronal production by human neural progenitor cells via a PAR1-PAR3-S1PR1-Akt pathway Journal of Neuroscience  2013 33:6181-6190  DOI:10.1523/jneurosci.4491-12.2013  PMID:23554499
  • Wang, Y. M., Zhang, Z. G., Chow, N., Davis, T. P., Griffin, J. H., Chopp, M., Zlokovic, B. V. An activated protein c analog with reduced anticoagulant activity extends the therapeutic window of tissue plasminogen activator for ischemic stroke in rodents Stroke  2012 43:2444-2449  DOI:10.1161/strokeaha.112.658997  PMID:22811462  PMCID:PMC3429704
  • Zhong, Z. H., Ilieva, H., Hallagan, L., Bell, R., Singh, I., Paquette, N., Thiyagarajan, M., Deane, R., Fernandez, J. A., Lane, S., Zlokovic, A. B., Liu, T., et al. Activated protein C therapy slows ALS-like disease in mice by transcriptionally inhibiting SOD1 in motor neurons and microglia cells Journal of Clinical Investigation  2009 119:3437-3449  DOI:10.1172/jci38476  PMID:19841542  PMCID:PMC2769191
  • Guo, H., Wang, Y. M., Singh, I., Liu, D., Fernandez, J. A., Griffin, J. H., Chow, N., Zlokovic, B. V. Species-dependent neuroprotection by activated protein C mutants with reduced anticoagulant activity Journal of Neurochemistry  2009 109:116-124  DOI:10.1111/j.1471-4159.2009.05921.x  PMID:19166505  PMCID:PMC2692505
  • Guo, H., Singh, I., Wang, Y. M., Deane, R., Barrett, T., Fernandez, J. A., Chow, N., Griffin, J. H., Zlokovic, B. V. Neuroprotective activities of activated protein C mutant with reduced anticoagulant activity European Journal of Neuroscience  2009 29:1119-1130  DOI:10.1111/j.1460-9568.2009.06664.x  PMID:19302148  PMCID:PMC2692517