related to degree

• Dickerson, Tobin, Ph.D. in Chemistry, Scripps Research , with Dr. Kim Janda 2000 - 2004

authors

• Dickerson, Tobin
• Yamamoto, N.
• Ruiz, D. I.
• Janda, Kim

publication date

• September 2004

journal

• Journal of the American Chemical Society  Journal

abstract

• The drug of abuse methamphetamine has been found to participate in the aberrant glycation of proteins. The importance of this chemical process has been shown wherein mouse albumin was readily modified with methamphetamine, and injection of this protein into mice yields a significant immune response, even in the absence of adjuvants. Competition experiments revealed that although methamphetamine binds weakly to the elicited antibodies, the primary epitope is composed of both the methamphetamine moiety and glucose-derived cross-linking region. Implications of this phenonomenon in the context of drug addiction are discussed.

subject areas

• Central Nervous System Stimulants
• Enzyme-Linked Immunosorbent Assay
• Glucose
• Glycosylation End Products, Advanced
• Methamphetamine
• Serum Albumin, Bovine

International Standard Serial Number (ISSN)

• 0002-7863

Digital Object Identifier (DOI)

• 10.1021/ja047690h

PubMed ID

• 15366884

start page

• 11446

end page

• 11447

volume

• 126

issue

• 37