recent publications
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academic article
- Burnett, R., Melander, C., Puckett, J. W., Son, L. S., Wells, R. D., Dervan, P. B., Gottesfeld, J. M. DNA sequence-specific polyamides alleviate transcription inhibition associated with long GAA.TTC repeats in Friedreich's ataxia Proceedings of the National Academy of Sciences of the United States of America 2006 103:11497-11502 DOI:10.1073/pnas.0604939103 PMID:16857735 PMCID:PMC1544198
- Gearhart, M. D., Dickinson, L., Ehley, J., Melander, C., Dervan, P. B., Wright, P. E., Gottesfeld, J. M. Inhibition of DNA binding by human estrogen-related receptor 2 and estrogen receptor alpha with minor groove binding polyamides Biochemistry 2005 44:4196-4203 DOI:10.1021/bi047872o PMID:15766247
- Dickinson, L. A., Burnett, R., Melander, C., Edelson, B. S., Arora, P. S., Dervan, P. B., Gottesfeld, J. M. Arresting cancer proliferation by small-molecule gene regulation Chemistry & Biology 2004 11:1583-1594 DOI:10.1016/j.chembiol.2004.09.004 PMID:15556009
- Melander, C., Burnett, R., Gottesfeld, J. M. Regulation of gene expression with pyrrole-imidazole polyamides Journal of Biotechnology 2004 112:195-220 DOI:10.1016/j.jbiotec.2004.03.018 PMID:15288953
- Dudouet, B., Burnett, R., Dickinson, L. A., Wood, M. R., Melander, C., Belitsky, J. M., Edelson, B., Wurtz, N., Briehn, C., Dervan, P. B., Gottesfeld, J. M. Accessibility of nuclear chromatin by DNA binding polyamides Chemistry & Biology 2003 10:859-867 DOI:10.1016/j.chembiol.2003.09.001 PMID:14522056
- Suto, R. K., Edayathumangalam, R. S., White, C. L., Melander, C., Gottesfeld, J. M., Dervan, P. B., Luger, K. Crystal structures of nucleosome core particles in complex with minor groove DNA-binding ligands Journal of Molecular Biology 2003 326:371-380 DOI:10.1016/s0022-2836(02)01407-9 PMID:12559907
- Gottesfeld, J. M., Belitsky, J. M., Melander, C., Dervan, P. B., Luger, K. Blocking transcription through a nucleosome with synthetic DNA ligands Journal of Molecular Biology 2002 321:249-263 DOI:10.1016/s0022-2836(02)00598-3 PMID:12144782
- Ehley, J. A., Melander, C., Herman, D., Baird, E. E., Ferguson, H. A., Goodrich, J. A., Dervan, P. B., Gottesfeld, J. M. Promoter scanning for transcription inhibition with DNA-binding polyamides Molecular and Cellular Biology 2002 22:1723-1733 DOI:10.1128/mcb.22.6.1723-1733.2002 PMID:11865052
- Gottesfeld, J. M., Melander, C., Suto, R. K., Raviol, H., Luger, K., Dervan, P. B. Sequence-specific recognition of DNA in the nucleosome by pyrrole-imidazole polyamides Journal of Molecular Biology 2001 309:615-629 DOI:10.1006/jmbi.2001.4694 PMID:11397084