Scripps VIVO scripps research logo

  • Index
  • Log in
  • Home
  • People
  • Organizations
  • Research
  • Events
Search form
As of April 1st VIVO Scientific Profiles will no longer updated for faculty, and the link to VIVO will be removed from the library website. Faculty profile pages will continue to be updated via Interfolio. VIVO will continue being used behind the scenes to update graduate student profiles. Please contact helplib@scripps.edu if you have questions.
How to download citations from VIVO | Alternative profile options

The novel ets factor tel2 cooperates with myc in b lymphomagenesis

Academic Article
uri icon
  • Overview
  • Identity
  • Additional Document Info
  • View All
scroll to property group menus

Overview

authors

  • Cardone, M.
  • Kandilci, A.
  • Carella, C.
  • Nilsson, J. A.
  • Brennan, J. A.
  • Sirma, S.
  • Ozbek, U.
  • Boyd, K.
  • Cleveland, John
  • Grosveld, G. C.

publication date

  • March 2005

journal

  • Molecular and Cellular Biology  Journal

abstract

  • The human ETS family gene TEL2/ETV7 is highly homologous to TEL1/ETV6, a frequent target of chromosome translocations in human leukemia and specific solid tumors. Here we report that TEL2 augments the proliferation and survival of normal mouse B cells and dramatically accelerates lymphoma development in Emu-Myc transgenic mice. Nonetheless, inactivation of the p53 pathway was a hallmark of all TEL2/Emu-Myc lymphomas, indicating that TEL2 expression alone is insufficient to bypass this apoptotic checkpoint. Although TEL2 is infrequently up-regulated in human sporadic Burkitt's lymphoma, analysis of pediatric B-cell acute lymphocytic leukemia (B-ALL) samples showed increased coexpression of TEL2 and MYC and/or MYCN in over one-third of B-ALL patients. Therefore, TEL2 and MYC also appear to cooperate in provoking a cadre of human B-cell malignancies.

subject areas

  • Animals
  • Apoptosis
  • B-Lymphocytes
  • Burkitt Lymphoma
  • Cell Proliferation
  • Child
  • DNA-Binding Proteins
  • Female
  • Humans
  • Male
  • Mice
  • Mice, Transgenic
  • Mutation
  • Proto-Oncogene Proteins c-ets
  • Proto-Oncogene Proteins c-myc
  • Suppression, Genetic
  • Transcription Factors
  • Tumor Suppressor Protein p53
  • Up-Regulation
scroll to property group menus

Identity

International Standard Serial Number (ISSN)

  • 0270-7306

Digital Object Identifier (DOI)

  • 10.1128/mcb.25.6.2395-2405.2005

PubMed ID

  • 15743832
scroll to property group menus

Additional Document Info

start page

  • 2395

end page

  • 2405

volume

  • 25

issue

  • 6

©2022 The Scripps Research Institute | Terms of Use | Powered by VIVO

  • About
  • Contact Us
  • Support