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The lymphoproliferating cells of mrl-lpr/lpr mice are a polyclonal population that bear the lymphocyte-t receptor for antigen

Academic Article
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Overview

authors

  • Nemazee, David
  • Studer, S.
  • Steinmetz, M.
  • Dembic, Z.
  • Kiefer, M.

publication date

  • 1985

journal

  • European Journal of Immunology  Journal

abstract

  • Mice bearing the recessive gene lpr develop an age-dependent, massive lymphoproliferation, primarily in the lymph nodes (LN), with associated autoimmunity. LN cells from these mice express T cell receptor protein on the cell surface at 50-70% of normal levels. Normal levels of T cell receptor alpha, beta and gamma mRNA were found in these cells as compared to normal LN cells. Southern blot analysis of MRL-lpr/lpr LN DNA showed rearrangements in 80-90% of the chromosomes at the beta gene loci. The pattern of rearrangement indicated that a polyclonal rather than monoclonal expansion of T cells occurred. These data support a lymphokine-induction model of lymphoproliferation in MRL-lpr mice.

subject areas

  • Animals
  • Antibodies, Monoclonal
  • Binding Sites, Antibody
  • Female
  • Gene Expression Regulation
  • Mice
  • Mice, Inbred BALB C
  • Mice, Inbred Strains
  • RNA, Messenger
  • Receptors, Antigen, T-Cell
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Identity

International Standard Serial Number (ISSN)

  • 0014-2980

Digital Object Identifier (DOI)

  • 10.1002/eji.1830150804

PubMed ID

  • 4029256
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Additional Document Info

start page

  • 760

end page

  • 764

volume

  • 15

issue

  • 8

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