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Sws1 is a conserved regulator of homologous recombination in eukaryotic cells

Academic Article
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Overview

authors

  • Martin, V.
  • Chahwan, C.
  • Gao, H.
  • Blais, V.
  • Wohlschlegel, J.
  • Yates III, John
  • McGowan, C. H.
  • Russell, Paul

publication date

  • June 2006

journal

  • EMBO Journal  Journal

abstract

  • Rad52-dependent homologous recombination (HR) is regulated by the antirecombinase activities of Srs2 and Rqh1/Sgs1 DNA helicases in fission yeast and budding yeast. Functional analysis of Srs2 in Schizosaccharomyces pombe led us to the discovery of Sws1, a novel HR protein with a SWIM-type Zn finger. Inactivation of Sws1 suppresses the genotoxic sensitivity of srs2Delta and rqh1Delta mutants and rescues the inviability of srs2Delta rqh1Delta cells. Sws1 functions at an early step of recombination in a pro-recombinogenic complex with Rlp1 and Rdl1, two RecA-like proteins that are most closely related to the human Rad51 paralogs XRCC2 and RAD51D, respectively. This finding indicates that the XRCC2-RAD51D complex is conserved in lower eukaryotes. A SWS1 homolog exists in human cells. It associates with RAD51D and ablating its expression reduces the number of RAD51 foci. These studies unveil a conserved pathway for the initiation and control of HR in eukaryotic cells.

subject areas

  • Amino Acid Sequence
  • Animals
  • DNA Helicases
  • Epistasis, Genetic
  • Humans
  • Molecular Sequence Data
  • Rad51 Recombinase
  • Recombination, Genetic
  • Saccharomyces cerevisiae Proteins
  • Schizosaccharomyces
  • Schizosaccharomyces pombe Proteins
  • Sequence Alignment
  • Sequence Homology, Amino Acid
  • Two-Hybrid System Techniques
  • Zinc Fingers
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Research

keywords

  • DNA repair
  • genome stability
  • homologous recombination
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Identity

PubMed Central ID

  • PMC1478202

International Standard Serial Number (ISSN)

  • 0261-4189

Digital Object Identifier (DOI)

  • 10.1038/sj.emboj.7601141

PubMed ID

  • 16710300
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Additional Document Info

start page

  • 2564

end page

  • 2574

volume

  • 25

issue

  • 11

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