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roX1 RNA paints the X chromosome of male Drosophila and is regulated by the dosage compensation system

Academic Article
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Overview

authors

  • Meller, V. H.
  • Wu, K. H.
  • Roman, G.
  • Kuroda, M. I.
  • Davis, Ronald

publication date

  • February 1997

journal

  • Cell  Journal

abstract

  • The Drosophila roX1 gene is X-linked and produces RNAs that are male-specific, somatic, and preferentially expressed in the central nervous system. These RNAs are retained in the nucleus and lack any significant open reading frame. Although all sexually dimorphic characteristics in Drosophila were thought to be controlled by the sex determination pathway through the gene transformer (tra), the expression of roX1 is independent of tra activity. Instead, the dosage compensation system is necessary and sufficient for the expression of roX1. Consistent with a potential function in dosage compensation, roX1 RNAs localize specifically to the male X chromosome. This localization occurs even when roX1 RNAs are expressed from autosomal locations in X-to-autosome translocations. The novel regulation and subnuclear localization of roX1 RNAs makes them candidates for an RNA component of the dosage compensation machinery.

subject areas

  • Animals
  • Base Sequence
  • Blastoderm
  • Chromosomal Proteins, Non-Histone
  • DNA Helicases
  • DNA-Binding Proteins
  • Drosophila Proteins
  • Drosophila melanogaster
  • Female
  • Gene Dosage
  • Gene Expression Regulation, Developmental
  • Genetic Linkage
  • In Situ Hybridization
  • Insect Hormones
  • Male
  • Molecular Sequence Data
  • Mutation
  • Nuclear Proteins
  • Open Reading Frames
  • RNA
  • RNA-Binding Proteins
  • Sex Characteristics
  • Sex Determination Analysis
  • Transcription Factors
  • Transcription, Genetic
  • X Chromosome
  • Y Chromosome
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Identity

International Standard Serial Number (ISSN)

  • 0092-8674

Digital Object Identifier (DOI)

  • 10.1016/s0092-8674(00)81885-1

PubMed ID

  • 9038336
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Additional Document Info

start page

  • 445

end page

  • 457

volume

  • 88

issue

  • 4

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