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Molecular basis for the generation in pigs of influenza a viruses with pandemic potential

Academic Article
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Overview

authors

  • Ito, T.
  • Couceiro, Jnss
  • Kelm, S.
  • Baum, L. G.
  • Krauss, S.
  • Castrucci, M. R.
  • Donatelli, I.
  • Kida, H.
  • Paulson, James
  • Webster, R. G.
  • Kawaoka, Y.

publication date

  • September 1998

journal

  • Journal of Virology  Journal

abstract

  • Genetic and biologic observations suggest that pigs may serve as "mixing vessels" for the generation of human-avian influenza A virus reassortants, similar to those responsible for the 1957 and 1968 pandemics. Here we demonstrate a structural basis for this hypothesis. Cell surface receptors for both human and avian influenza viruses were identified in the pig trachea, providing a milieu conducive to viral replication and genetic reassortment. Surprisingly, with continued replication, some avian-like swine viruses acquired the ability to recognize human virus receptors, raising the possibility of their direct transmission to human populations. These findings help to explain the emergence of pandemic influenza viruses and support the need for continued surveillance of swine for viruses carrying avian virus genes.

subject areas

  • Adaptation, Biological
  • Amino Acid Sequence
  • Amino Acids
  • Animals
  • Binding Sites
  • Ducks
  • Hemagglutinin Glycoproteins, Influenza Virus
  • Humans
  • Influenza A virus
  • Molecular Sequence Data
  • Phylogeny
  • Receptors, Virus
  • Sequence Homology, Amino Acid
  • Swine
  • Trachea
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Identity

PubMed Central ID

  • PMC109961

International Standard Serial Number (ISSN)

  • 0022-538X

PubMed ID

  • 9696833
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Additional Document Info

start page

  • 7367

end page

  • 7373

volume

  • 72

issue

  • 9

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