recent publications

• academic article

  • Villanueva, C. J., Vergnes, L., Wang, J., Drew, B. G., Hong, C., Tu, Y., Hu, Y., Peng, X., Feng, X., Saez, E., Wroblewski, K., Hevener, A. L., et al. Adipose subtype-selective recruitment of TLE3 or Prdm16 by PPARγ specifies lipid storage versus thermogenic gene programs Cell Metabolism  2013 17:423-435  DOI:10.1016/j.cmet.2013.01.016  PMID:23473036  PMCID:PMC3626567
  • Villanueva, C. J., Waki, H., Godio, C., Nielsen, R., Chou, W. L., Vargas, L., Wroblewski, K., Schmedt, C., Chao, L. C., Boyadjian, R., Mandrup, S., Hevener, A., et al. Tle3 is a dual-function transcriptional coregulator of adipogenesis Cell Metabolism  2011 13:413-427  DOI:10.1016/j.cmet.2011.02.014  PMID:21459326  PMCID:PMC3089971
  • Molteni, V., Li, X., Nabakka, J., Liang, F., Wityak, J., Koder, A., Vargas, L., Romeo, R., Mitro, N., Mak, P. A., Seidel, M., Haslam, J. A., et al. N-acylthiadiazolines, a new class of liver x receptor agonists with selectivity for lxr beta Journal of Medicinal Chemistry  2007 50:4255-4259  DOI:10.1021/jm070453f  PMID:17665897
  • Joseph, S. B., Bradley, M. N., Castrillo, A., Bruhn, K. W., Mak, P. A., Pei, L. M., Hogenesch, J., O'Connell, R. M., Cheng, G. H., Saez, E., Miller, J. F., Tontonoz, P. Lxr-dependent gene expression is important for macrophage survival and the innate immune response Cell  2004 119:299-309  DOI:10.1016/j.cell.2004.09.032  PMID:15479645
  • Laffitte, B. A., Chao, L. C., Li, J., Walczak, R., Hummasti, S., Joseph, S. B., Castrillo, A., Wilpitz, D. C., Mangelsdorf, D. J., Collins, J. L., Saez, E., Tontonoz, P. Activation of liver x receptor improves glucose tolerance through coordinate regulation of glucose metabolism in liver and adipose tissue Proceedings of the National Academy of Sciences of the United States of America  2003 100:5419-5424  DOI:10.1073/pnas.0830671100  PMID:12697904  PMCID:PMC154360
  • Mak, P. A., Laffitte, B. A., Desrumaux, C., Joseph, S. B., Curtiss, L. K., Mangelsdorf, D. J., Tontonoz, P., Edwards, P. A. Regulated expression of the apolipoprotein e/c-i/c-iv/c-ii gene cluster in murine and human macrophages - a critical role for nuclear liver x receptors alpha and beta Journal of Biological Chemistry  2002 277:31900-31908  DOI:10.1074/jbc.M202993200  PMID:12032151
  • Chawla, A., Boisvert, W. A., Lee, C. H., Laffitte, B. A., Barak, Y., Joseph, S. B., Liao, D., Nagy, L., Edwards, P. A., Curtiss, L. K., Evans, R. M., Tontonoz, P. A ppar gamma-lxr-abca1 pathway in macrophages is involved in cholesterol efflux and atherogenesis Molecular Cell  2001 7:161-171  DOI:10.1016/s1097-2765(01)00164-2  PMID:11172721
  • Saez, E., Tontonoz, P., Nelson, M. C., Alvarez, J. G. A., U, T. M., Baird, S. M., Thomazy, V. A., Evans, R. M. Activators of the nuclear receptor ppar gamma enhance colon polyp formation Nature Medicine  1998 4:1058-1061  DOI:10.1038/2042  PMID:9734400