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Systemic ethanol: selective enhancement of responses to acetylcholine and somatostatin in hippocampus

Academic Article
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Overview

authors

  • Mancillas, J. R.
  • Siggins, George
  • Bloom, Floyd

publication date

  • January 1986

journal

  • Science  Journal

abstract

  • In rat hippocampal pyramidal cells tested in situ by iontophoresis of several neurotransmitters, ethanol significantly enhanced excitatory responses to acetylcholine and inhibitory responses to somatostatin-14 but had no statistically significant effect on excitatory responses to glutamate or inhibitory responses to gamma-aminobutyric acid or, in preliminary tests, to norepinephrine or serotonin. The effects of ethanol on responses to acetylcholine and somatostatin-14 may provide insight into synaptic mechanisms underlying the behavioral consequences of ethanol intoxication.

subject areas

  • Acetylcholine
  • Action Potentials
  • Animals
  • Ethanol
  • Goldfish
  • Hippocampus
  • Male
  • Neurons
  • Norepinephrine
  • Rats
  • Rats, Inbred Strains
  • Serotonin
  • Somatostatin
  • Synaptic Membranes
  • gamma-Aminobutyric Acid
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Identity

International Standard Serial Number (ISSN)

  • 0036-8075

Digital Object Identifier (DOI)

  • 10.1126/science.2867600

PubMed ID

  • 2867600
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Additional Document Info

start page

  • 161

end page

  • 163

volume

  • 231

issue

  • 4734

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