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A crf2 agonist administered into the central nucleus of the amygdala decreases ethanol self-administration in ethanol-dependent rats

Academic Article
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Overview

authors

  • Funk, C. K.
  • Koob, George

publication date

  • June 2007

journal

  • Brain Research  Journal

abstract

  • Alcohol dependence is characterized by excessive consumption, loss of control over intake and the presence of a withdrawal syndrome, including both motivational and physical symptoms. Previous studies have implicated the brain corticotropin-releasing factor (CRF) stress systems in mediating the negative emotional state associated with ethanol withdrawal. CRF(1) receptor-specific antagonists, administered systemically, and CRF receptor subtype nonspecific antagonists, administered into the central nucleus of the amygdala (CeA), selectively decrease the anxiety-like behaviors and increased ethanol self-administration associated with ethanol withdrawal. In the present study, we investigated the role of CRF(2) receptors within the CeA in mediating ethanol self-administration in ethanol-dependent and nondependent animals. Male Wistar rats were made dependent on ethanol using an intermittent ethanol vapor exposure paradigm. Nondependent animals received similar conditions but were exposed to air only. Following 2 h of withdrawal from ethanol vapors, ethanol and water self-administration were measured following administration of urocortin 3, a highly selective CRF(2) agonist, in the CeA. In dependent rats, urocortin 3 (0.1 microg/microl and 0.5 microg/microl) decreased ethanol self-administration, with no effect on water self-administration. In nondependent rats, urocortin 3 (0.5 microg/microl) increased ethanol self-administration, with no effect on water self-administration. These data demonstrate an opposing role of the CRF(2) receptor subtype within the CeA in mediating ethanol self-administration in withdrawn, dependent and nondependent rats.

subject areas

  • Alcohol Drinking
  • Alcoholism
  • Amygdala
  • Animals
  • Corticotropin-Releasing Hormone
  • Drinking Behavior
  • Rats
  • Receptors, Corticotropin-Releasing Hormone
  • Self Administration
  • Water
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Research

keywords

  • alcohol
  • corticotropin-releasing factor receptor
  • dependence
  • self-administration
  • urocortin
  • withdrawal
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Identity

PubMed Central ID

  • PMC2741495

International Standard Serial Number (ISSN)

  • 0006-8993

Digital Object Identifier (DOI)

  • 10.1016/j.brainres.2007.04.009

PubMed ID

  • 17512918
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Additional Document Info

start page

  • 172

end page

  • 178

volume

  • 1155

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