recent publications

• academic article

  • Caetano, C., Limbo, O., Farmer, S., Klier, S., Dovey, C., Russell, P., de Bruin, R. A. M. Tolerance of deregulated G1/S transcription depends on critical G1/S regulon genes to prevent catastrophic genome instability Cell Reports  2014 9:2279-2289  DOI:10.1016/j.celrep.2014.11.039  PMID:25533348
  • Bertoli, C., Klier, S., McGowan, C., Wittenberg, C., de Bruin, R. A. M. Chk1 inhibits E2F6 repressor function in response to replication stress to maintain cell-cycle transcription Current Biology  2013 23:1629-1637  DOI:10.1016/j.cub.2013.06.063  PMID:23954429  PMCID:PMC3977652
  • Travesa, A., Kalashnikova, T. I., de Bruin, R. A. M., Cass, S. R., Chahwan, C., Lee, D. E., Lowndes, N. F., Wittenberg, C. Repression of G1/S transcription is mediated via interaction of the GTB motifs of Nrm1 and Whi5 with Swi6 Molecular and Cellular Biology  2013 33:1476-1486  DOI:10.1128/mcb.01333-12  PMID:23382076  PMCID:PMC3624247
  • Travesa, A., Kuo, D., de Bruin, R. A. M., Kalashnikova, T. I., Guaderrama, M., Thai, K., Aslanian, A., Smolka, M. B., Yates, J. R., Ideker, T., Wittenberg, C. DNA replication stress differentially regulates G1/S genes via Rad53-dependent inactivation of Nrm1 EMBO Journal  2012 31:1811-1822  DOI:10.1038/emboj.2012.28  PMID:22333915  PMCID:PMC3321207
  • de Bruin, R. A. M., Wittenberg, C. All eukaryotes: Before turning off g(1)-s transcription, please check your DNA Cell Cycle  2009 8:214-217  DOI:10.4161/cc.8.2.7412  PMID:19158488
  • Wagner, M. V., Smolka, M. B., de Bruin, R. A. M., Zhou, H. L., Wittenberg, C., Dowdy, S. F. Whi5 regulation by site specific cdk-phosphorylation in saccharomyces cerevisiae PLoS One  2009 4:e4300  DOI:10.1371/journal.pone.0004300  PMID:19172996  PMCID:PMC2627923
  • de Bruin, R. A. M., Kalashnikova, T. I., Aslanian, A., Wohischlegel, J., Chahwan, C., Yates, J. R., Russell, P., Wittenberg, C. DNA replication checkpoint promotes G1-S transcription by inactivating the MBF repressor Nrm1 Proceedings of the National Academy of Sciences of the United States of America  2008 105:11230-11235  DOI:10.1073/pnas.0801106105  PMID:18682565  PMCID:PMC2516226
  • de Bruin, R. A. M., Kalashnikova, T. I., Wittenberg, C. Stb1 collaborates with other regulators to modulate the g(1)-specific transcriptional circuit Molecular and Cellular Biology  2008 28:6919-6928  DOI:10.1128/mcb.00211-08  PMID:18794370  PMCID:PMC2573305
  • Ashe, M., de Bruin, R. A. M., Kalashnikova, T., McDonald, W. H., Yates, J. R., Wittenberg, C. The SBF- and MBF-associated protein Msa1 is required for proper timing of G(1)-specific transcription in Saccharomyces cerevisiae Journal of Biological Chemistry  2008 283:6040-6049  DOI:10.1074/jbc.M708248200  PMID:18160399
  • Limbo, O., Chahwan, C., Yamada, Y., de Bruin, R. A. M., Wittenberg, C., Russell, P. Ctp1 is a cell-cycle-regulated protein that functions with Mre11 complex to control double-strand break repair by homologous recombination Molecular Cell  2007 28:134-146  DOI:10.1016/j.molcel.2007.09.009  PMID:17936710  PMCID:PMC2066204
  • de Bruin, R. A. M., Kalashnikova, T. I., Chahwan, C., McDonald, W. H., Wohlschlegel, J., Yates, J., Russell, P., Wittenberg, C. Constraining G1-specific transcription to late G1 phase: the MBF-associated corepressor Nrm1 acts via negative feedback Molecular Cell  2006 23:483-496  DOI:10.1016/j.molcel.2006.06.025  PMID:16916637
  • de Bruin, R. A. M., McDonald, W. H., Kalashnikova, T. I., Yates, J., Wittenberg, C. Cln3 activates G1-specific transcription via phosphorylation of the SBF transcription bound repressor Whi5 Cell  2004 117:887-898  DOI:10.1016/j.cell.2004.05.025  PMID:15210110