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Inhibition of nitric oxide synthesis reduces intravenous cocaine self-administration in the rat

Academic Article
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Overview

authors

  • Pulvirenti, Luigi
  • Balducci, C.
  • Koob, George

publication date

  • 1996

journal

  • Neuropharmacology  Journal

abstract

  • The effects of a blockade of nitric oxide synthesis were studied in rats trained to self-administer cocaine intravenously. Pretreatment with Ng-nitro-1-arginine methyl ester (l-NAME; 10-50 mg/kg, intraperitoneally, twice daily for 4 days), significantly and dose-dependently suppressed the maintenance of intravenous cocaine self-administration and the absolute reward magnitude of cocaine. These results suggest that nitric oxide may play a role in cocaine abuse and dependence.

subject areas

  • Animals
  • Cocaine
  • Dose-Response Relationship, Drug
  • Enzyme Inhibitors
  • Male
  • NG-Nitroarginine Methyl Ester
  • Nitric Oxide Synthase
  • Opioid-Related Disorders
  • Rats
  • Rats, Wistar
  • Reward
  • Self Administration
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Research

keywords

  • cocaine
  • drug dependence
  • l-NAME
  • nitric oxide
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Identity

International Standard Serial Number (ISSN)

  • 0028-3908

Digital Object Identifier (DOI)

  • 10.1016/s0028-3908(96)00152-9

PubMed ID

  • 9076761
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Additional Document Info

start page

  • 1811

end page

  • 1814

volume

  • 35

issue

  • 12

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