Scripps VIVO scripps research logo

  • Index
  • Log in
  • Home
  • People
  • Organizations
  • Research
  • Events
Search form
As of April 1st VIVO Scientific Profiles will no longer updated for faculty, and the link to VIVO will be removed from the library website. Faculty profile pages will continue to be updated via Interfolio. VIVO will continue being used behind the scenes to update graduate student profiles. Please contact helplib@scripps.edu if you have questions.
How to download citations from VIVO | Alternative profile options

Recognition of bacterial glycosphingolipids by natural killer T cells

Academic Article
uri icon
  • Overview
  • Identity
  • Additional Document Info
  • View All
scroll to property group menus

Overview

related to degree

  • Wu, Douglass, Ph.D. in Chemistry, Scripps Research 2001 - 2006

authors

  • Kinjo, Y.
  • Wu, Douglass
  • Kim, G. S.
  • Xing, G. W.
  • Poles, M. A.
  • Ho, D. D.
  • Tsuji, M.
  • Kawahara, K.
  • Wong, Chi-Huey
  • Kronenberg, M.

publication date

  • March 2005

journal

  • Nature  Journal

abstract

  • Natural killer T (NKT) cells constitute a highly conserved T lymphocyte subpopulation that has the potential to regulate many types of immune responses through the rapid secretion of cytokines. NKT cells recognize glycolipids presented by CD1d, a class I-like antigen-presenting molecule. They have an invariant T-cell antigen receptor (TCR) alpha-chain, but whether this invariant TCR recognizes microbial antigens is still controversial. Here we show that most mouse and human NKT cells recognize glycosphingolipids from Sphingomonas, Gram-negative bacteria that do not contain lipopolysaccharide. NKT cells are activated in vivo after exposure to these bacterial antigens or bacteria, and mice that lack NKT cells have a marked defect in the clearance of Sphingomonas from the liver. These data suggest that NKT cells are T lymphocytes that provide an innate-type immune response to certain microorganisms through recognition by their antigen receptor, and that they might be useful in providing protection from bacteria that cannot be detected by pattern recognition receptors such as Toll-like receptor 4.

subject areas

  • Animals
  • Antigens, Bacterial
  • Antigens, CD1
  • Antigens, CD1d
  • Cells, Cultured
  • Dendritic Cells
  • Glycosphingolipids
  • Humans
  • Hybridomas
  • Killer Cells, Natural
  • Liver
  • Mice
  • Mice, Inbred C57BL
  • Mice, Transgenic
  • Sphingomonas
  • T-Lymphocyte Subsets
scroll to property group menus

Identity

International Standard Serial Number (ISSN)

  • 0028-0836

Digital Object Identifier (DOI)

  • 10.1038/nature03407

PubMed ID

  • 15791257
scroll to property group menus

Additional Document Info

start page

  • 520

end page

  • 525

volume

  • 434

issue

  • 7032

©2022 The Scripps Research Institute | Terms of Use | Powered by VIVO

  • About
  • Contact Us
  • Support