recent publications

• academic article

  • Johnson, E. F., Connick, J. P., Reed, J. R., Backes, W. L., Desai, M. C., Xu, L., Estrada, D. F., Laurence, J. S., Scott, E. E. Correlating structure and function of drug-metabolizing enzymes: progress and ongoing challenges Drug Metabolism and Disposition  2014 42:9-22  DOI:10.1124/dmd.113.054627  PMID:24130370  PMCID:PMC3876788
  • Joyce, M. G., Kanekiyo, M., Xu, L., Biertumpfel, C., Boyington, J. C., Moquin, S., Shi, W., Wu, X., Yang, Y., Yang, Z. Y., Zhang, B., Zheng, A., et al. Outer domain of HIV-1 gp120: antigenic optimization, structural malleability, and crystal structure with antibody VRC-PG04 Journal of Virology  2013 87:2294-2306  DOI:10.1128/jvi.02717-12  PMID:23236069  PMCID:PMC3571475
  • Klionsky, D. J., Abdalla, F. C., Abeliovich, H., Abraham, R. T., Acevedo-Arozena, A., Adeli, K., Agholme, L., Agnello, M., Agostinis, P., Aguirre-Ghiso, J. A., Ahn, H. J., Ait-Mohamed, O., et al. Guidelines for the use and interpretation of assays for monitoring autophagy Autophagy  2012 8:445-544  DOI:10.4161/auto.19496  PMID:22966490  PMCID:PMC3404883
  • Du, S. X., Xu, L., Zhang, W. G., Tang, S., Boenig, R. I., Chen, H., Mariano, E. B., Zwick, M. B., Parren, Pwhi, Burton, D. R., Wrin, T., Petropoulos, C. J., et al. A directed molecular evolution approach to improved immunogenicity of the hiv-1 envelope glycoprotein PLoS One  2011 6:e20927  DOI:10.1371/journal.pone.0020927  PMID:21738594  PMCID:PMC3126809
  • Wu, X. L., Yang, Z. Y., Li, Y. X., Hogerkorp, C. M., Schief, W. R., Seaman, M. S., Zhou, T. Q., Schmidt, S. D., Wu, L., Xu, L., Longo, N. S., McKee, K., et al. Rational design of envelope identifies broadly neutralizing human monoclonal antibodies to hiv-1 Science  2010 329:856-861  DOI:10.1126/science.1187659  PMID:20616233  PMCID:PMC2965066
  • Zhou, T., Georgiev, I., Wu, X., Yang, Z. Y., Dai, K., Finzi, A., Kwon, Y. D., Scheid, J. F., Shi, W., Xu, L., Yang, Y., Zhu, J., et al. Structural basis for broad and potent neutralization of HIV-1 by antibody VRC01 Science  2010 329:811-817  DOI:10.1126/science.1192819  PMID:20616231  PMCID:PMC2981354
  • Kashyap, A. K., Steel, J., Rubrum, A., Estelles, A., Briante, R., Ilyushina, N. A., Xu, L., Swale, R. E., Faynboym, A. M., Foreman, P. K., Horowitz, M., Horowitz, L., et al. Protection from the 2009 h1n1 pandemic influenza by an antibody from combinatorial survivor-based libraries PLoS Pathogens  2010 6:e1000990  DOI:10.1371/journal.ppat.1000990  PMID:20628565  PMCID:PMC2900296
  • Xu, L., Estelles, A., Briante, R., Kurtzman, A. L., Hannum, C. H., Kashyap, A. K., Horowitz, L., Horowitz, M., Bhatt, R. R., Lerner, R. A. Surrobodies with functional tails Journal of Molecular Biology  2010 397:352-360  DOI:10.1016/j.jmb.2010.01.036  PMID:20100493
  • Chen, L., Kwon, Y. D., Zhou, T. Q., Wu, X. L., O'Dell, S., Cavacini, L., Hessell, A. J., Pancera, M., Tang, M., Xu, L., Yang, Z. Y., Zhang, M. Y., et al. Structural basis of immune evasion at the site of cd4 attachment on hiv-1 gp120 Science  2009 326:1123-1127  DOI:10.1126/science.1175868  PMID:19965434  PMCID:PMC2862588
  • Wu, L., Zhou, T. Q., Yang, Z. Y., Svehla, K., O'Dell, S., Louder, M. K., Xu, L., Mascola, J. R., Burton, D. R., Hoxie, J. A., Doms, R. W., Kwong, P. D., et al. Enhanced exposure of the cd4-binding site to neutralizing antibodies by structural design of a membrane-anchored human immunodeficiency virus type 1 gp120 domain Journal of Virology  2009 83:5077-5086  DOI:10.1128/jvi.02600-08  PMID:19264769  PMCID:PMC2682083
  • Dey, B., Svehla, K., Xu, L., Wycuff, D., Voss, G., Phogat, A., Chakrabarti, B. K., Li, Y. X., Shaw, G., Kwong, P. D., Nabel, G. J., Mascola, J. R. Structure-based stabilization of hiv-1 gp120 enhances humoral immune responses to the induced co-receptor binding site PLoS Pathogens  2009 5:e1000445  DOI:10.1371/journal.ppat.1000445  PMID:19478876  PMCID:PMC2680979
  • Xu, L., Yee, H., Chan, C., Kashyap, A. K., Horowitz, L., Horowitz, M., Bhatt, R. R., Lerner, R. A. Combinatorial surrobody libraries Proceedings of the National Academy of Sciences of the United States of America  2008 105:10756-10761  DOI:10.1073/pnas.0805293105  PMID:18664586  PMCID:PMC2504838
  • Wei, C. J., Xu, L., Kong, W. P., Shi, W., Canis, K., Stevens, J., Yang, Z. Y., Dell, A., Haslam, S. M., Wilson, I. A., Nabel, G. J. Comparative efficacy of neutralizing antibodies elicited by recombinant hemagglutinin proteins from avian h5n1 influenza virus Journal of Virology  2008 82:6200-6208  DOI:10.1128/jvi.00187-08  PMID:18417563  PMCID:PMC2447076
  • Frazer, K. A., Ballinger, D. G., Cox, D. R., Hinds, D. A., Stuve, L. L., Gibbs, R. A., Belmont, J. W., Boudreau, A., Hardenbol, P., Leal, S. M., Pasternak, S., Wheeler, D. A., et al. A second generation human haplotype map of over 3.1 million SNPs Nature  2007 449:851-861  DOI:10.1038/nature06258  PMID:17943122  PMCID:PMC2689609
  • Sabeti, P. C., Varilly, P., Fry, B., Lohmueller, J., Hostetter, E., Cotsapas, C., Xie, X. H., Byrne, E. H., McCarroll, S. A., Gaudet, R., Schaffner, S. F., Lander, E. S. Genome-wide detection and characterization of positive selection in human populations Nature  2007 449:913-918  DOI:10.1038/nature06250  PMID:17943131  PMCID:PMC2687721
  • Xu, L., Chong, Y. H., Hwang, I. Y., D'Onofrio, A., Amore, K., Beardsley, G. P., Li, C. L., Olson, A. J., Boger, D. L., Wilson, I. A. Structure-based design, synthesis, evaluation, and crystal structures of transition state analogue inhibitors of inosine monophosphate cyclohydrolase Journal of Biological Chemistry  2007 282:13033-13046  DOI:10.1074/jbc.M607293200  PMID:17324932
  • Zhou, T. Q., Xu, L., Dey, B., Hessell, A. J., Van Ryk, D., Xiang, S. H., Yang, X., Zhang, M. Y., Zwick, M. B., Arthos, J., Burton, D. R., Dimitrov, D. S., et al. Structural definition of a conserved neutralization epitope on HIV-1 gp120 Nature  2007 445:732-737  DOI:10.1038/nature05580  PMID:17301785  PMCID:PMC2584968
  • Letvin, N. L., Mascola, J. R., Sun, Y., Gorgone, D. A., Buzby, A. P., Xu, L., Yang, Z. Y., Chakrabarti, B., Rao, S. S., Schmitz, J. E., Montefiori, D. C., Barker, B. R., et al. Preserved cd4(+) central memory t cells and survival in vaccinated siv-challenged monkeys Science  2006 312:1530-1533  DOI:10.1126/science.1124226  PMID:16763152  PMCID:PMC2365913
  • DeMartino, J. K., Hwang, I., Xu, L., Wilson, I. A., Boger, D. L. Discovery of a potent, nonpolyglutamatable inhibitor of glycinamide ribonucleotide transformylase Journal of Medicinal Chemistry  2006 49:2998-3002  DOI:10.1021/jm0601147  PMID:16686541  PMCID:PMC2531195
  • Altshuler, D., Brooks, L. D., Chakravarti, A., Collins, F. S., Daly, M. J., Donnelly, P., Gibbs, R. A., Belmont, J. W., Boudreau, A., Leal, S. M., Hardenbol, P., Pasternak, S., et al. A haplotype map of the human genome Nature  2005 437:1299-1320  DOI:10.1038/nature04226  PMID:16255080  PMCID:PMC1880871
  • Santra, S., Seaman, M. S., Xu, L., Barouch, D. H., Lord, C. I., Lifton, M. A., Gorgone, D. A., Beaudry, K. R., Svehla, K., Welcher, B., Chakrabarti, B. K., Huang, Y., et al. Replication-defective adenovirus serotype 5 vectors elicit durable cellular and humoral immune responses in nonhuman primates Journal of Virology  2005 79:6516-6522  DOI:10.1128/jvi.79.10.6516-6522.2005  PMID:15858035
  • Seaman, M. S., Xu, L., Beaudry, K., Martin, K. L., Beddall, M. H., Miura, A., Sambor, A., Chakrabarti, B. K., Huang, Y., Bailer, R., Koup, R. A., Mascola, J. R., et al. Multiclade human immunodeficiency virus type 1 envelope immunogens elicit broad cellular and humoral immunity in rhesus monkeys Journal of Virology  2005 79:2956-2963  DOI:10.1128/jvi.79.5.2956-2963.2005  PMID:15709015
  • Mascola, J. R., Sambor, A., Beaudry, K., Santra, S., Welcher, B., Louder, M. K., VanCott, T. C., Huang, Y., Chakrabarti, B. K., Kong, W. P., Yang, Z. Y., Xu, L., et al. Neutralizing antibodies elicited by immunization of monkeys with DNA plasmids and recombinant adenoviral vectors expressing human immunodeficiency virus type 1 proteins Journal of Virology  2005 79:771-779  DOI:10.1128/jvi.79.2.771-779.2005  PMID:15613305
  • Li, C. L., Xu, L., Wolan, D. W., Wilson, I. A., Olson, A. J. Virtual screening of human 5-aminoimidazole-4-carboxamide ribonucleotide transformylase against the NCI diversity set by use of AutoDock to identify novel nonfolate inhibitors Journal of Medicinal Chemistry  2004 47:6681-6690  DOI:10.1021/jm049504o  PMID:15615517
  • Xu, L., Li, C. L., Olson, A. J., Wilson, I. A. Crystal structure of avian aminoimidazole-4-carboxamide ribonucleotide transformylase in complex with a novel non-folate inhibitor identified by virtual ligand screening Journal of Biological Chemistry  2004 279:50555-50565  DOI:10.1074/jbc.M406801200  PMID:15355974
  • Letvin, N. L., Huang, Y., Chakrabarti, B. K., Xu, L., Seaman, M. S., Beaudry, K., Korioth-Schmitz, B., Yu, F., Rohne, D., Martin, K. L., Miura, A., Kong, W. P., et al. Heterologous envelope immunogens contribute to aids vaccine protection in rhesus monkeys Journal of Virology  2004 78:7490-7497  DOI:10.1128/jvi.78.14.7490-7497.2004  PMID:15220422
  • Yang, Z. Y., Chakrabarti, B. K., Xu, L., Welcher, B., Kong, W. P., Leung, K., Panet, A., Mascola, J. R., Nabel, G. J. Selective modification of variable loops alters tropism and enhances immunogenicity of human immunodeficiency virus type 1 envelope Journal of Virology  2004 78:4029-4036  DOI:10.1128/jvi.78.8.4029-4036.2004  PMID:15047819
  • Barouch, D. H., McKay, P. F., Sumida, S. M., Santra, S., Jackson, S. S., Gorgone, D. A., Lifton, M. A., Chakrabarti, B. K., Xu, L., Nabel, G. J., Letvin, N. L. Plasmid chemokines and colony-stimulating factors enhance the immunogenicity of DNA priming-viral vector boosting human immunodeficiency virus type 1 vaccines Journal of Virology  2003 77:8729-8735  DOI:10.1128/jvi.77.16.8729-8735.2003  PMID:12885892
  • Baig, J., Levy, D. B., McKay, P. F., Schmitz, J. E., Santra, S., Subbramanian, R. A., Kuroda, M. J., Lifton, M. A., Gorgone, D. A., Wyatt, L. S., Moss, B., Huang, Y., et al. Elicitation of simian immunodeficiency virus-specific cytotoxic t lymphocytes in mucosal compartments of rhesus monkeys by systemic vaccination Journal of Virology  2002 76:11484-11490  DOI:10.1128/jvi.76.22.11484-11490.2002  PMID:12388710
  • Rosenblum, C. I., Tota, M., Cully, D., Smith, T., Collum, R., Qureshi, S., Hess, J. F., Phillips, M. S., Hey, P. J., Vongs, A., Fong, T. M., Xu, L., et al. Functional STAT 1 and 3 signaling by the leptin receptor (OB-R): reduced expression of the rat fatty leptin receptor in transfected cells Endocrinology  1996 137:5178-5181  DOI:10.1210/en.137.11.5178  PMID:8895396