recent publications

• academic article

  • Yamada, D. H., Elsaesser, H., Lux, A., Timmerman, J. M., Morrison, S. L., de la Torre, J. C., Nimmerjahn, F., Brooks, D. G. Suppression of Fcγ-receptor-mediated antibody effector function during persistent viral infection Immunity  2015 42:379-390  DOI:10.1016/j.immuni.2015.01.005  PMID:25680277  PMCID:PMC4334737
  • Gillespie, E. J., Ho, C. L. C., Balaji, K., Clemens, D. L., Deng, G., Wang, Y. E., Elsaesser, H. J., Tamilselvam, B., Gargi, A., Dixon, S. D., France, B., Chamberlain, B. T., et al. Selective inhibitor of endosomal trafficking pathways exploited by multiple toxins and viruses Proceedings of the National Academy of Sciences of the United States of America  2013 110:E4904-E4912  DOI:10.1073/pnas.1302334110  PMID:24191014  PMCID:PMC3864319
  • Ng, C. T., Snell, L. M., Brooks, D. G., Oldstone, M. B. A. Networking at the level of host immunity: immune cell interactions during persistent viral infections Cell Host & Microbe  2013 13:652-664  DOI:10.1016/j.chom.2013.05.014  PMID:23768490  PMCID:PMC3713852
  • Brooks, D. G., Walsh, K. B., Elsaesser, H., Oldstone, M. B. A. Il-10 directly suppresses cd4 but not cd8 t cell effector and memory responses following acute viral infection Proceedings of the National Academy of Sciences of the United States of America  2010 107:3018-3023  DOI:10.1073/pnas.0914500107  PMID:20133700  PMCID:PMC2840337
  • Elsaesser, H., Sauer, K., Brooks, D. G. Il-21 is required to control chronic viral infection Science  2009 324:1569-1572  DOI:10.1126/science.1174182  PMID:19423777  PMCID:PMC2830017
  • Brooks, D. G., Ha, S. J., Elsaesser, H., Sharpe, A. H., Freeman, G. J., Oldstone, M. B. A. IL-10 and PD-L1 operate through distinct pathways to suppress T-cell activity during persistent viral infection Proceedings of the National Academy of Sciences of the United States of America  2008 105:20428-20433  DOI:10.1073/pnas.0811139106  PMID:19075244  PMCID:PMC2629263
  • Brooks, D. G., Lee, A. M., Elsaesser, H., McGavern, D. B., Oldstone, M. B. A. Il-10 blockade facilitates DNA vaccine-induced t cell responses and enhances clearance of persistent virus infection Journal of Experimental Medicine  2008 205:533-541  DOI:10.1084/jem.20071948  PMID:18332180  PMCID:PMC2275377
  • Brooks, D. G., Trifilo, M. J., Edelmann, K. H., Teyton, L., McGavern, D. B., Oldstone, M. B. A. Interleukin-10 determines viral clearance or persistence in vivo Nature Medicine  2006 12:1301-1309  DOI:10.1038/nm1492  PMID:17041596  PMCID:PMC2535582
  • Brooks, D. G., McGavern, D. B., Oldstone, M. B. A. Reprogramming of antiviral t cells prevents inactivation and restores t cell activity during persistent viral infection Journal of Clinical Investigation  2006 116:1675-1685  DOI:10.1172/jci26856  PMID:16710479
  • Brooks, D. G., Teyton, L., Oldstone, M. B. A., McGavern, D. B. Intrinsic functional dysregulation of CD4 T cells occurs rapidly following persistent viral infection Journal of Virology  2005 79:10514-10527  DOI:10.1128/jvi.79.16.10514-10527.2005  PMID:16051844  PMCID:PMC1182641