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Adding amino acids to the genetic repertoire

Academic Article
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Overview

related to degree

  • Xie, Jianming, Ph.D. in Chemistry, Scripps Research 2001 - 2006

authors

  • Xie, Jianming
  • Schultz, Peter

publication date

  • December 2005

journal

  • Current Opinion in Chemical Biology  Journal

abstract

  • Considerable progress has been made in expanding the number and nature of genetically encoded amino acids in Escherichia coli, yeast and mammalian cells in the past four years. To date, over 30 unnatural amino acids have been cotranslationally incorporated into proteins with high fidelity and efficiency by means of a unique codon and corresponding orthogonal tRNA-aminoacyl-tRNA synthetase pair. The incorporated amino acids contain spectroscopic probes, post-translational modifications, metal chelators, photoaffinity labels and unique functional groups. The ability to genetically encode additional amino acids, beyond the common 20, provides a powerful approach for probing protein structure and function both in vitro and in vivo, as well as generating proteins with new or enhanced properties.

subject areas

  • Amino Acids
  • Amino Acyl-tRNA Synthetases
  • Escherichia coli
  • Models, Biological
  • Protein Biosynthesis
  • Protein Engineering
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Identity

International Standard Serial Number (ISSN)

  • 1367-5931

Digital Object Identifier (DOI)

  • 10.1016/j.cbpa.2005.10.011

PubMed ID

  • 16260173
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Additional Document Info

start page

  • 548

end page

  • 554

volume

  • 9

issue

  • 6

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