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A receptor in pituitary and hypothalamus that functions in growth hormone release

Academic Article
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Overview

authors

  • Howard, A. D.
  • Feighner, S. D.
  • Cully, D. F.
  • Arena, J. P.
  • Liberator, P. A.
  • Rosenblum, C. I.
  • Hamelin, M.
  • Hreniuk, D. L.
  • Palyha, O. C.
  • Anderson, J.
  • Paress, P. S.
  • Diaz, C.
  • Chou, M.
  • Liu, K. K.
  • McKee, K. K.
  • Pong, S. S.
  • Chaung, L. Y.
  • Elbrecht, A.
  • Dashkevicz, M.
  • Heavens, R.
  • Rigby, M.
  • Sirinathsinghji, D. J. S.
  • Dean, D. C.
  • Melillo, D. G.
  • Patchett, A. A.
  • Nargund, R.
  • Griffin, Patrick
  • DeMartino, J. A.
  • Gupta, S. K.
  • Schaeffer, J. M.
  • Smith, Roy
  • VanderPloeg, L. H. T.

publication date

  • 1996

journal

  • Science  Journal

abstract

  • Small synthetic molecules termed growth hormone secretagogues (GHSs) act on the pituitary gland and the hypothalamus to stimulate and amplify pulsatile growth hormone (GH) release. A heterotrimeric GTP-binding protein (G protein)-coupled receptor (GPC-R) of the pituitary and arcuate ventro-medial and infundibular hypothalamus of swine and humans was cloned and was shown to be the target of the GHSs. On the basis of its pharmacological and molecular characterization, this GPC-R defines a neuroendocrine pathway for the control of pulsatile GH release and supports the notion that the GHSs mimic an undiscovered hormone.

subject areas

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Cell Line
  • Codon
  • DNA, Complementary
  • GTP-Binding Proteins
  • Growth Hormone
  • Hormones
  • Humans
  • Hypothalamus, Middle
  • Indoles
  • Macaca mulatta
  • Molecular Sequence Data
  • Oligopeptides
  • Pituitary Gland
  • RNA, Complementary
  • Rats
  • Receptors, Cell Surface
  • Receptors, G-Protein-Coupled
  • Receptors, Ghrelin
  • Spiro Compounds
  • Swine
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Identity

International Standard Serial Number (ISSN)

  • 0036-8075

Digital Object Identifier (DOI)

  • 10.1126/science.273.5277.974

PubMed ID

  • 8688086
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Additional Document Info

start page

  • 974

end page

  • 977

volume

  • 273

issue

  • 5277

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