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Risk factors for intracranial hemorrhage and nonhemorrhagic stroke after fibrinolytic therapy (from the gusto-i trial)

Academic Article
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Overview

authors

  • Kandzari, D. E.
  • Granger, C. B.
  • Simoons, M. L.
  • White, H. D.
  • Simes, J.
  • Mahaffey, K. W.
  • Gore, J.
  • Weaver, W. D.
  • Longstreth, W. T.
  • Stebbins, A.
  • Lee, K. L.
  • Califf, R. M.
  • Topol, Eric
  • Investigators, Gusto- I.

publication date

  • February 2004

journal

  • American Journal of Cardiology  Journal

abstract

  • Of 592 patients in the Global Utilization of Streptokinase and tPA for Occluded Arteries-I trial who had a stroke during initial hospitalization, the risk for intracranial hemorrhage was significantly greater in those with recent facial or head trauma (odds ratio 13.0, 95% confidence interval 3.4 to 85.5); dementia was additionally associated with an increased risk for intracranial hemorrhage (odds ratio 3.4, 95% confidence interval 1.2 to 10.2). Because facial or head trauma may greatly influence treatment decisions, this risk factor should be incorporated into models designed to estimate the risks and benefits of fibrinolytic therapy.

subject areas

  • Aged
  • Case-Control Studies
  • Chi-Square Distribution
  • Female
  • Humans
  • Intracranial Hemorrhages
  • Male
  • Middle Aged
  • Myocardial Infarction
  • Odds Ratio
  • Prospective Studies
  • Risk Factors
  • Streptokinase
  • Stroke
  • Thrombolytic Therapy
  • Tissue Plasminogen Activator
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Identity

International Standard Serial Number (ISSN)

  • 0002-9149

Digital Object Identifier (DOI)

  • 10.1016/j.amjcard.2003.10.043

PubMed ID

  • 14969623
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Additional Document Info

start page

  • 458

end page

  • 461

volume

  • 93

issue

  • 4

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