Scripps VIVO scripps research logo

  • Index
  • Log in
  • Home
  • People
  • Organizations
  • Research
  • Events
Search form
As of April 1st VIVO Scientific Profiles will no longer updated for faculty, and the link to VIVO will be removed from the library website. Faculty profile pages will continue to be updated via Interfolio. VIVO will continue being used behind the scenes to update graduate student profiles. Please contact helplib@scripps.edu if you have questions.
How to download citations from VIVO | Alternative profile options

Regulation of circadian behaviour and metabolism by synthetic REV-ERB agonists

Academic Article
uri icon
  • Overview
  • Identity
  • Additional Document Info
  • View All
scroll to property group menus

Overview

authors

  • Solt, Laura A.
  • Wang, Y. J.
  • Banerjee, S.
  • Hughes, T.
  • Kojetin, Douglas
  • Lundasen, T.
  • Shin, Y.
  • Liu, J.
  • Cameron, Michael
  • Noel, R.
  • Yoo, S. H.
  • Takahashi, J. S.
  • Butler, Andrew
  • Kamenecka, Theodore
  • Burris, Thomas

publication date

  • May 2012

journal

  • Nature  Journal

abstract

  • Synchronizing rhythms of behaviour and metabolic processes is important for cardiovascular health and preventing metabolic diseases. The nuclear receptors REV-ERB-α and REV-ERB-β have an integral role in regulating the expression of core clock proteins driving rhythms in activity and metabolism. Here we describe the identification of potent synthetic REV-ERB agonists with in vivo activity. Administration of synthetic REV-ERB ligands alters circadian behaviour and the circadian pattern of core clock gene expression in the hypothalami of mice. The circadian pattern of expression of an array of metabolic genes in the liver, skeletal muscle and adipose tissue was also altered, resulting in increased energy expenditure. Treatment of diet-induced obese mice with a REV-ERB agonist decreased obesity by reducing fat mass and markedly improving dyslipidaemia and hyperglycaemia. These results indicate that synthetic REV-ERB ligands that pharmacologically target the circadian rhythm may be beneficial in the treatment of sleep disorders as well as metabolic diseases.

subject areas

  • Adipose Tissue
  • Animals
  • Biological Clocks
  • Circadian Rhythm
  • Disease Models, Animal
  • Energy Metabolism
  • HEK293 Cells
  • Humans
  • Hypothalamus
  • Liver
  • Metabolome
  • Mice
  • Mice, Inbred BALB C
  • Mice, Inbred C57BL
  • Muscle, Skeletal
  • Nuclear Receptor Subfamily 1, Group D, Member 1
  • Obesity
  • Pyrrolidines
  • Receptors, Cytoplasmic and Nuclear
  • Repressor Proteins
  • Thiophenes
scroll to property group menus

Identity

PubMed Central ID

  • PMC3343186

International Standard Serial Number (ISSN)

  • 0028-0836

Digital Object Identifier (DOI)

  • 10.1038/nature11030

PubMed ID

  • 22460951
scroll to property group menus

Additional Document Info

start page

  • 62

end page

  • 68

volume

  • 485

issue

  • 7396

©2022 The Scripps Research Institute | Terms of Use | Powered by VIVO

  • About
  • Contact Us
  • Support