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ANKTM1, a TRP-like channel expressed in nociceptive neurons, is activated by cold temperatures

Academic Article
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Overview

authors

  • Story, G. M.
  • Peier, A. M.
  • Reeve, A. J.
  • Eid, S. R.
  • Mosbacher, J.
  • Hricik, T. R.
  • Earley, T. J.
  • Hergarden, A. C.
  • Andersson, D. A.
  • Hwang, S. W.
  • McIntyre, P.
  • Jegla, T.
  • Bevan, S.
  • Patapoutian, Ardem

publication date

  • March 2003

journal

  • Cell  Journal

abstract

  • Mammals detect temperature with specialized neurons in the peripheral nervous system. Four TRPV-class channels have been implicated in sensing heat, and one TRPM-class channel in sensing cold. The combined range of temperatures that activate these channels covers a majority of the relevant physiological spectrum sensed by most mammals, with a significant gap in the noxious cold range. Here, we describe the characterization of ANKTM1, a cold-activated channel with a lower activation temperature compared to the cold and menthol receptor, TRPM8. ANKTM1 is a distant family member of TRP channels with very little amino acid similarity to TRPM8. It is found in a subset of nociceptive sensory neurons where it is coexpressed with TRPV1/VR1 (the capsaicin/heat receptor) but not TRPM8. Consistent with the expression of ANKTM1, we identify noxious cold-sensitive sensory neurons that also respond to capsaicin but not to menthol.

subject areas

  • Amino Acid Sequence
  • Animals
  • Ankyrins
  • CHO Cells
  • Calcium Channels
  • Capsaicin
  • Cells, Cultured
  • Cold Temperature
  • Cricetinae
  • Female
  • Membrane Proteins
  • Mice
  • Molecular Sequence Data
  • Nerve Tissue Proteins
  • Neurons, Afferent
  • Nociceptors
  • Protein Structure, Tertiary
  • Rats
  • Rats, Sprague-Dawley
  • TRPC Cation Channels
  • Thermoreceptors
  • Transient Receptor Potential Channels
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Identity

International Standard Serial Number (ISSN)

  • 0092-8674

Digital Object Identifier (DOI)

  • 10.1016/s0092-8674(03)00158-2

PubMed ID

  • 12654248
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Additional Document Info

start page

  • 819

end page

  • 829

volume

  • 112

issue

  • 6

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