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Epidermal T cells and wound healing

Academic Article
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Overview

authors

  • Havran, Wendy
  • Jameson, Julie

publication date

  • May 2010

journal

  • Journal of Immunology  Journal

abstract

  • The murine epidermis contains resident T cells that express a canonical gammadelta TCR. These cells arise from fetal thymic precursors and use a TCR that is restricted to the skin in adult animals. These cells assume a dendritic morphology in normal skin and constitutively produce low levels of cytokines that contribute to epidermal homeostasis. When skin is wounded, an unknown Ag is expressed on damaged keratinocytes. Neighboring gammadelta T cells then round up and contribute to wound healing by local production of epithelial growth factors and inflammatory cytokines. In the absence of skin gammadelta T cells, wound healing is impaired. Similarly, epidermal T cells from patients with healing wounds are activated and secreting growth factors. Patients with nonhealing wounds have a defective epidermal T cell response. Information gained on the role of epidermal-resident T cells in the mouse may provide information for development of new therapeutic approaches to wound healing.

subject areas

  • Animals
  • Cell Communication
  • Dendritic Cells
  • Epidermis
  • Homeostasis
  • Humans
  • Receptors, Antigen, T-Cell, gamma-delta
  • T-Lymphocyte Subsets
  • Wound Healing
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Identity

PubMed Central ID

  • PMC2944652

International Standard Serial Number (ISSN)

  • 0022-1767

Digital Object Identifier (DOI)

  • 10.4049/jimmunol.0902733

PubMed ID

  • 20483798
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Additional Document Info

start page

  • 5423

end page

  • 5428

volume

  • 184

issue

  • 10

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