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Development of pharmacotherapies for drug addiction: a Rosetta stone approach

Academic Article
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Overview

authors

  • Koob, George
  • Lloyd, G. K.
  • Mason, Barbara

publication date

  • June 2009

journal

  • Nature Reviews Drug Discovery  Journal

abstract

  • Current pharmacotherapies for addiction represent opportunities for facilitating treatment and are forming a foundation for evaluating new medications. Furthermore, validated animal models of addiction and a surge in understanding of neurocircuitry and neuropharmacological mechanisms involved in the development and maintenance of addiction - such as the neuroadaptive changes that account for the transition to dependence and the vulnerability to relapse - have provided numerous potential therapeutic targets. Here, we emphasize a 'Rosetta Stone approach', whereby existing pharmacotherapies for addiction are used to validate and improve animal and human laboratory models to identify viable new treatment candidates. This approach will promote translational research and provide a heuristic framework for developing efficient and effective pharmacotherapies for addiction.

subject areas

  • Animals
  • Drug Discovery
  • Drug Evaluation, Preclinical
  • Humans
  • Nerve Net
  • Pharmaceutical Preparations
  • Substance-Related Disorders
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Identity

PubMed Central ID

  • PMC2760328

International Standard Serial Number (ISSN)

  • 1474-1776

Digital Object Identifier (DOI)

  • 10.1038/nrd2828

PubMed ID

  • 19483710
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Additional Document Info

start page

  • 500

end page

  • 515

volume

  • 8

issue

  • 6

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