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Lysis of human cultured lymphoblastoid cells by cell-induced activation of properdin pathway

Academic Article
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Overview

authors

  • Theofilopoulos, Argyrios
  • Perrin, L. H.

publication date

  • 1977

journal

  • Science  Journal

abstract

  • Human cultured lymphoblastoid cells incubated in normal human serum activate the properdin complement pathway without antibody. However, only cells bearing C3b immune adherence receptors bind components of the properdin complement pathway and undergo lysis. A similar surveillance mechanism may exist in man to limit growth of malignant B cells bearing C3b immune adherence receptors.

subject areas

  • B-Lymphocytes
  • Binding Sites
  • Cell Line
  • Complement C3
  • Complement System Proteins
  • Cytotoxicity Tests, Immunologic
  • Edetic Acid
  • Egtazic Acid
  • Humans
  • Kinetics
  • Properdin
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Identity

International Standard Serial Number (ISSN)

  • 0036-8075

Digital Object Identifier (DOI)

  • 10.1126/science.402691

PubMed ID

  • 402691
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Additional Document Info

start page

  • 878

end page

  • 880

volume

  • 195

issue

  • 4281

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