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Intraventricular corticotropin-releasing factor enhances behavioral-effects of novelty

Academic Article
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Overview

authors

  • Britton, D. R.
  • Koob, George
  • Rivier, J.
  • Vale, W.

publication date

  • 1982

journal

  • Life Sciences  Journal

abstract

  • Corticotropin-releasing factor was administered into the lateral cerebral ventricles of rats. Sixty minutes later, animals were tested in an open field conflict test or in their home cages for a variety of behaviors which have been shown to be related to the degree of responsiveness to novelty. CRF, in a dose related fashion, altered the frequency of those behaviors which are normally expressed in response to the novel environment. Specifically, CRF caused an increase in grooming and decreases in the amount of rearing, the number of approaches to a food pellet placed in the center of the open field, the amount of food eaten in both the open field and the home cage and a decrease in the mean amount of food eaten per approach to the food pedestal.

subject areas

  • Animals
  • Behavior, Animal
  • Cerebral Ventricles
  • Corticotropin-Releasing Hormone
  • Dose-Response Relationship, Drug
  • Eating
  • Environment
  • Exploratory Behavior
  • Feeding Behavior
  • Grooming
  • Male
  • Rats
  • Rats, Inbred Strains
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Identity

International Standard Serial Number (ISSN)

  • 0024-3205

Digital Object Identifier (DOI)

  • 10.1016/0024-3205(82)90416-7

PubMed ID

  • 6983018
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Additional Document Info

start page

  • 363

end page

  • 367

volume

  • 31

issue

  • 4

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