recent publications

• academic article

  • Nettles, K. W., Gil, G., Nowak, J., Metivier, R., Sharma, V. B., Greene, G. L. CBP is a dosage-dependent regulator of nuclear factor-kappa B suppression by the estrogen receptor Molecular Endocrinology  2008 22:263-272  DOI:10.1210/me.2007-0324  PMID:17932106  PMCID:PMC2234588
  • Nettles, K. W., Bruning, J. B., Gil, G., Nowak, J., Sharma, S. K., Hahm, J. B., Kulp, K., Hochberg, R. B., Zhou, H., Katzenellenbogen, J. A., Katzenellenbogen, B. S., Kim, Y., et al. NF kappa B selectivity of estrogen receptor ligands revealed by comparative crystallographic analyses Nature Chemical Biology  2008 4:241-247  DOI:10.1038/nchembio.76  PMID:18344977  PMCID:PMC2659626
  • Zhou, H. B., Nettles, K. W., Bruning, J. B., Kim, Y., Joachimiak, A., Sharma, S., Carlson, K. E., Stossi, F., Katzenellenbogen, B. S., Greene, G. L., Katzenellenbogen, J. A. Elemental isomerism: A boron-nitrogen surrogate for a carbon-carbon double bond increases the chemical diversity of estrogen receptor ligands Chemistry & Biology  2007 14:659-669  DOI:10.1016/j.chembiol.2007.04.009  PMID:17584613
  • Nettles, K. W., Bruning, J. B., Gil, G., O'Neill, E. E., Nowak, J., Guo, Y., Kim, Y., DeSombre, E. R., Dilis, R., Hanson, R. N., Joachimiak, A., Greene, G. L. Structural plasticity in the oestrogen receptor ligand-binding domain EMBO Reports  2007 8:563-568  DOI:10.1038/sj.embor.7400963  PMID:17468738  PMCID:PMC2002528
  • Zhou, H. B., Sheng, S. B., Compton, D. R., Kim, Y., Joachimiak, A., Sharma, S., Carlson, K. E., Katzenellenbogen, B. S., Nettles, K. W., Greene, G. L., Katzenellenbogen, J. A. Structure-guided optimization of estrogen receptor binding affinity and antagonist potency of pyrazolopyrimidines with basic side chains Journal of Medicinal Chemistry  2007 50:399-403  DOI:10.1021/jm061035y  PMID:17228884
  • Nettles, K. W., Greene, G. L. Ligand control of coregulator recruitment to nuclear receptors Annual Review of Physiology  2005 67:309-333  DOI:10.1146/annurev.physiol.66.032802.154710  PMID:15709961
  • Nettles, K. W., Sun, J., Radek, J. T., Sheng, S. B., Rodriguez, A. L., Katzenellenbogen, J. A., Katzenellenbogen, B. S., Greene, G. L. Allosteric control of ligand selectivity between estrogen receptors alpha and beta: Implications for other nuclear receptors Molecular Cell  2004 13:317-327  DOI:10.1016/s1097-2765(04)00054-1  PMID:14967140
  • Nettles, K. W., Greene, G. L. Nuclear receptor ligands and cofactor recruitment: is there a coactivator "on deck"? Molecular Cell  2003 11:850-851  DOI:10.1016/s1097-2765(03)00133-3  PMID:12718871
  • Shiau, A. K., Barstad, D., Radek, J. T., Meyers, M. J., Nettles, K. W., Katzenellenbogen, B. S., Katzenellenbogen, J. A., Agard, D. A., Greene, G. L. Structural characterization of a subtype-selective ligand reveals a novel mode of estrogen receptor antagonism Nature Structural Biology  2002 9:359-364  DOI:10.1038/nsb787  PMID:11953755
  • Raymoure, W. J., McNaught, R. W., Greene, G. L., Smith, R. G. Receptor interconversion model of hormone action. II. Nucleotide-mediated conversion of estrogen receptors from nonsteroid binding to the lower affinity binding state Journal of Biological Chemistry  1986 261:7018-7025  PMID:3023379
  • Venter, J. C., Berzofsky, J. A., Lindstrom, J., Jacobs, S., Fraser, C. M., Kohn, L. D., Schneider, W. J., Greene, G. L., Strosberg, A. D., Erlanger, B. F. Monoclonal and anti-idiotypic antibodies as probes for receptor structure and function Federation Proceedings  1984 43:2532-2539  PMID:6203777