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The role of retinoblastoma-associated proteins 46 and 48 in estrogen receptor alpha mediated gene expression

Academic Article
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Overview

authors

  • Creekmore, A. L.
  • Walt, K. A.
  • Schultz-Norton, J. R.
  • Ziegler, Y. S.
  • McLeod, I. X.
  • Yates III, John
  • Nardulli, A. M.

publication date

  • September 2008

journal

  • Molecular and Cellular Endocrinology  Journal

abstract

  • The differential recruitment of coregulatory proteins to the DNA-bound estrogen receptor alpha (ERalpha) plays a critical role in mediating estrogen-responsive gene expression. We previously isolated and identified retinoblastoma-associated proteins 46 (RbAp46) and 48 (RbAp48), which are associated with chromatin remodeling, histone deacetylation, and transcription repression, as proteins associated with the DNA-bound ERalpha. We now demonstrate that RbAp46 and RbAp48 interact with ERalphain vitro and in vivo, associate with ERalpha at endogenous, estrogen-responsive genes, and alter expression of endogenous, ERalpha-activated and -repressed genes in MCF-7 breast cancer cells. Our findings reveal that RbAp48 limits expression of estrogen-responsive genes and that RbAp46 modulates estrogen responsiveness in a gene-specific manner. The ability of RbAp46 and RbAp48 to interact with ERalpha and influence its activity reveals yet another role for these multifunctional proteins in regulating gene expression.

subject areas

  • Breast Neoplasms
  • Carrier Proteins
  • Cell Line, Tumor
  • Estrogen Receptor alpha
  • Estrogens
  • Female
  • Gene Expression Regulation
  • Humans
  • Nuclear Proteins
  • Retinoblastoma-Binding Protein 4
  • Retinoblastoma-Binding Protein 7
  • Transcription, Genetic
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Research

keywords

  • RbAp46
  • RbAp48
  • estrogen receptor
  • retinoblastoma-associated protein
  • transcription
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Identity

PubMed Central ID

  • PMC2642675

International Standard Serial Number (ISSN)

  • 0303-7207

Digital Object Identifier (DOI)

  • 10.1016/j.mce.2008.05.016

PubMed ID

  • 18577416
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Additional Document Info

start page

  • 79

end page

  • 86

volume

  • 291

issue

  • 1-2

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