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Applications of laser-polarized (129)Xe to biomolecular assays

Academic Article
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Overview

authors

  • Lowery, T. J.
  • Rubin, S. M.
  • Ruiz, E. J.
  • Spence, M. M.
  • Winssinger, Nicolas
  • Schultz, Peter
  • Pines, Alexander
  • Wemmer, D. E.

publication date

  • December 2003

journal

  • Magnetic Resonance Imaging  Journal

abstract

  • The chemical shift sensitivity and significant signal enhancement afforded by laser-polarized 129Xe have motivated the application of 129Xe NMR to biological imaging and spectroscopy. Recent research done by our group has used laser-polarized 129Xe in biomolecular assays that detect ligand-binding events and distinguish protein conformations. The successful application of unfunctionalized and functionalized 129Xe NMR to in vitro biomolecular assays suggests the potential future use of a functionalized xenon biosensor for in vivo imaging.

subject areas

  • Humans
  • Lasers
  • Ligands
  • Nuclear Magnetic Resonance, Biomolecular
  • Protein Conformation
  • Xenon Isotopes
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Research

keywords

  • biosensor
  • ligand-protein interactions
  • protein conformation assay
  • xenon binding
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Identity

International Standard Serial Number (ISSN)

  • 0730-725X

Digital Object Identifier (DOI)

  • 10.1016/j.mri.2003.08.025

PubMed ID

  • 14725931
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Additional Document Info

start page

  • 1235

end page

  • 1239

volume

  • 21

issue

  • 10

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