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Sphingosine 1-phosphate and its receptors: An autocrine and paracrine network

Academic Article
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Overview

authors

  • Rosen, Hugh
  • Goetzl, E. J.

publication date

  • July 2005

journal

  • Nature Reviews Immunology  Journal

abstract

  • Sphingosine 1-phosphate (S1P) is a biologically active lysophospholipid that transmits signals through a family of G-protein-coupled receptors to control cellular differentiation and survival, as well as the vital functions of several types of immune cell. In this Review article, we discuss recent results that indicate that S1P and its receptors are required for the emigration of thymocytes from the thymus, the trafficking of lymphocytes in secondary lymphoid organs and the migration of B cells into splenic follicles. In an autocrine manner, through interactions with different G-protein-coupled receptors, S1P also enhances optimal mast-cell migration and release of pro-inflammatory mediators in allergic reactions. S1P-S1P-receptor regulatory systems might therefore be novel targets for the therapy of diverse immunological diseases.

subject areas

  • Animals
  • Autocrine Communication
  • Endothelial Cells
  • Lysophospholipids
  • Models, Animal
  • Paracrine Communication
  • Receptors, Lysosphingolipid
  • Sphingosine
  • T-Lymphocytes
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Identity

International Standard Serial Number (ISSN)

  • 1474-1733

Digital Object Identifier (DOI)

  • 10.1038/nri1650

PubMed ID

  • 15999095
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Additional Document Info

start page

  • 560

end page

  • 570

volume

  • 5

issue

  • 7

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