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Tak1 regulates multiple protein kinase cascades activated by bacterial lipopolysaccharide

Academic Article
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Overview

authors

  • Lee, Jiing-Dwan
  • Mira-Arbibe, L.
  • Ulevitch, Richard

publication date

  • December 2000

journal

  • Journal of Leukocyte Biology  Journal

abstract

  • During inflammation the balance between cell activation and cell death is determined by the tight regulation of multiple intracellular enzyme cascades. Key regulatory steps often involve protein kinases. We show that the prototypical pro-inflammatory molecule, bacterial lipopolysaccharide, activates multiple protein kinases such as p38, JNK, IKK-beta, and PKB/Akt via transforming growth factor beta-activated kinase-1 (TAK1). We also show that TAK1 plays an important role in similar activation pathways triggered by interleukin-1. Thus TAK1 must be considered as an important component of intracellular pathways in cells involved in host responses to physiological and/or environmental stress signals during inflammation.

subject areas

  • Androstadienes
  • Animals
  • Apoptosis
  • Cell Line
  • Chromones
  • Cysteine Proteinase Inhibitors
  • Enzyme Activation
  • Enzyme Inhibitors
  • Flavonoids
  • Humans
  • Hydrogen Peroxide
  • Hypertonic Solutions
  • I-kappa B Kinase
  • Imidazoles
  • Inflammation
  • Insulin-Like Growth Factor I
  • Interleukin-1
  • JNK Mitogen-Activated Protein Kinases
  • Lipopolysaccharides
  • MAP Kinase Kinase Kinases
  • MAP Kinase Signaling System
  • Mice
  • Mitogen-Activated Protein Kinases
  • Morpholines
  • NF-kappa B
  • Okadaic Acid
  • Phosphatidylinositol 3-Kinases
  • Prostaglandins A
  • Protein Kinases
  • Protein Serine-Threonine Kinases
  • Proto-Oncogene Proteins
  • Proto-Oncogene Proteins c-akt
  • Pyridines
  • Recombinant Fusion Proteins
  • Signal Transduction
  • Stress, Physiological
  • Transfection
  • Tumor Cells, Cultured
  • p38 Mitogen-Activated Protein Kinases
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Research

keywords

  • interleukin-1
  • intracellular signaling
  • transforming growth factor beta-activated kinase-1
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Identity

International Standard Serial Number (ISSN)

  • 0741-5400

PubMed ID

  • 11129660
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Additional Document Info

start page

  • 909

end page

  • 915

volume

  • 68

issue

  • 6

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