Scripps VIVO scripps research logo

  • Index
  • Log in
  • Home
  • People
  • Organizations
  • Research
  • Events
Search form
As of April 1st VIVO Scientific Profiles will no longer updated for faculty, and the link to VIVO will be removed from the library website. Faculty profile pages will continue to be updated via Interfolio. VIVO will continue being used behind the scenes to update graduate student profiles. Please contact helplib@scripps.edu if you have questions.
How to download citations from VIVO | Alternative profile options

Presynaptic antagonist-postsynaptic agonist at muscarinic cholinergic synapses. N-methyl-N-(1-methyl-4-pyrrolidino-2-butynyl)acetamide

Academic Article
uri icon
  • Overview
  • Identity
  • Additional Document Info
  • View All
scroll to property group menus

Overview

authors

  • Nordstrom, O.
  • Alberts, P.
  • Westlind, A.
  • Unden, A.
  • Bartfai, Tamas

publication date

  • 1983

journal

  • Molecular Pharmacology  Journal

abstract

  • A muscarinic cholinergic ligand, N-methyl-N-(1-methyl-4-pyrrolidino-2-butynyl)-acetamide (Compound BM-5), was shown to act simultaneously as a presynaptic antagonist and as a postsynaptic agonist at peripheral and central muscarinic synapses. In the presence of eserine it enhanced release of [3H]acetylcholine evoked by electrical stimulation in the guinea pig ileum longitudinal muscle myenteric plexus preparation. It also enhanced the release of [3H]acetylcholine evoked by potassium (25 mM) from rat hippocampal slices. It contracted the ileum and stimulated the synthesis of cyclic guanosine 3',5'-monophosphate in rat hippocampal slices and in human lymphocytes in a manner similar to the muscarinic agonist oxotremorine. This effect of BM-5 could be blocked by atropine.

subject areas

  • Acetylcholine
  • Animals
  • Binding, Competitive
  • Cyclic GMP
  • Guinea Pigs
  • Hippocampus
  • Humans
  • In Vitro Techniques
  • Lymphocytes
  • Male
  • Muscle Contraction
  • Muscle, Smooth
  • Parasympatholytics
  • Parasympathomimetics
  • Pyrrolidines
  • Quinuclidinyl Benzilate
  • Rats
  • Rats, Inbred Strains
  • Synapses
scroll to property group menus

Identity

International Standard Serial Number (ISSN)

  • 0026-895X

PubMed ID

  • 6306436
scroll to property group menus

Additional Document Info

start page

  • 1

end page

  • 5

volume

  • 24

issue

  • 1

©2022 The Scripps Research Institute | Terms of Use | Powered by VIVO

  • About
  • Contact Us
  • Support