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RGS6/G beta 5 complex accelerates IKaCh gating kinetics in atrial myocytes and modulates parasympathetic regulation of heart rate

Academic Article
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  • Research
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Overview

authors

  • Posokhova, E.
  • Wydeven, N.
  • Allen, K. L.
  • Wickman, K.
  • Martemyanov, Kirill

publication date

  • November 2010

journal

  • Circulation Research  Journal

subject areas

  • Animals
  • Down-Regulation
  • G Protein-Coupled Inwardly-Rectifying Potassium Channels
  • GTP-Binding Protein beta Subunits
  • HEK293 Cells
  • Heart Atria
  • Heart Rate
  • Humans
  • Ion Channel Gating
  • Mice
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Mice, Transgenic
  • Myocytes, Cardiac
  • Parasympathetic Fibers, Postganglionic
  • Potassium Channels, Voltage-Gated
  • RGS Proteins
  • Signal Transduction
  • Up-Regulation
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Research

keywords

  • G protein
  • GIRK
  • cardiac
  • knockout
  • muscarinic
  • regulators of G protein signaling
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Identity

PubMed Central ID

  • PMC3014848

International Standard Serial Number (ISSN)

  • 0009-7330

Digital Object Identifier (DOI)

  • 10.1161/circresaha.110.224212

PubMed ID

  • 20884879
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Additional Document Info

start page

  • 1350

end page

  • 1354

volume

  • 107

issue

  • 11

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