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Amantadine does not have antiviral activity against Borna disease virus

Academic Article
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Overview

authors

  • Cubitt, B.
  • de la Torre, Juan

publication date

  • 1997

journal

  • Archives of Virology  Journal

abstract

  • We have investigated the antiviral activity of amantadine (AD) against Borna disease virus (BDV) in several culture cell systems. We present evidence that AD, in the range 5 to 10 microM, does not have antiviral activity against BDV. Treatment of BDV infected cells with AD for six days caused neither a reduction in the number of infected cells, nor a decrease in steady state levels of BDV RNA or proteins. Moreover, treatment of cells with AD prior infection did not affect BDV multiplication, whereas influenza A virus yield was less than 1% with respect to that obtained in untreated control cells.

subject areas

  • Amantadine
  • Animals
  • Antigens, Viral
  • Antiviral Agents
  • Borna disease virus
  • Cell Line
  • Dogs
  • RNA, Viral
  • Rabbits
  • Rats
  • Tumor Cells, Cultured
  • Viral Proteins
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Identity

International Standard Serial Number (ISSN)

  • 0304-8608

Digital Object Identifier (DOI)

  • 10.1007/s007050050220

PubMed ID

  • 9413511
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Additional Document Info

start page

  • 2035

end page

  • 2042

volume

  • 142

issue

  • 10

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