recent publications

• academic article

  • Park, H., Gonzalez, A. L., Yildirim, I., Tran, T., Lohman, J. R., Fang, P., Guo, M., Disney, M. D. Crystallographic and computational analyses of AUUCU repeating RNA that causes spinocerebellar ataxia type 10 (SCA10) Biochemistry  2015 54:3851-3859  DOI:10.1021/acs.biochem.5b00551  PMID:26039897  PMCID:PMC4876817
  • Tran, T., Childs-Disney, J. L., Liu, B., Guan, L. R., Rzuczek, S., Disney, M. D. Targeting the r(CGG) repeats that cause FXTAS with modularly assembled small molecules and oligonucleotides ACS Chemical Biology  2014 9:904-912  DOI:10.1021/cb400875u  PMID:24506227  PMCID:PMC4287843
  • Childs-Disney, J. L., Yildirim, I., Park, H., Lohman, J. R., Guan, L., Tran, T., Sarkar, P., Schatz, G. C., Disney, M. D. Structure of the myotonic dystrophy type 2 RNA and designed small molecules that reduce toxicity ACS Chemical Biology  2014 9:538-550  DOI:10.1021/cb4007387  PMID:24341895  PMCID:PMC3944380
  • Childs-Disney, J. L., Stepniak-Konieczna, E., Tran, T., Yildirim, I., Park, H., Chen, C. Z., Hoskins, J., Southall, N., Marugan, J. J., Patnaik, S., Zheng, W., Austin, C. P., et al. Induction and reversal of myotonic dystrophy type 1 pre-mRNA splicing defects by small molecules Nature Communications  2013 4:2044  DOI:10.1038/ncomms3044  PMID:23806903  PMCID:PMC3710115
  • Sellier, C., Freyermuth, F., Tabet, R., Tran, T., He, F., Ruffenach, F., Alunni, V., Moine, H., Thibault, C., Page, A., Tassone, F., Willemsen, R., et al. Sequestration of DROSHA and DGCR8 by expanded CGG RNA repeats alters microRNA processing in Fragile X-associated tremor/ataxia syndrome Cell Reports  2013 3:869-880  DOI:10.1016/j.celrep.2013.02.004  PMID:23478018  PMCID:PMC3639429
  • Disney, M. D., Liu, B., Yang, W. Y., Sellier, C., Tran, T., Charlet-Berguerand, N., Childs-Disney, J. L. A small molecule that targets r(CGG)(exp) and improves defects in fragile X-associated tremor ataxia syndrome ACS Chemical Biology  2012 7:1711-1718  DOI:10.1021/cb300135h  PMID:22948243  PMCID:PMC3477254
  • Parkesh, R., Childs-Disney, J. L., Nakamori, M., Kumar, A., Wang, E., Wang, T., Hoskins, J., Tran, T., Housman, D., Thornton, C. A., Disney, M. D. Design of a bioactive small molecule that targets the myotonic dystrophy type 1 RNA via an RNA motif-ligand database and chemical similarity searching Journal of the American Chemical Society  2012 134:4731-4742  DOI:10.1021/ja210088v  PMID:22300544  PMCID:PMC3306011
  • Tran, T., Disney, M. D. Molecular recognition of 6 '-N-5-hexynoate kanamycin A and RNA 1x1 internal loops containing CA mismatches Biochemistry  2011 50:962-969  DOI:10.1021/bi101724h  PMID:21207945  PMCID:PMC3106427
  • Tran, T., Disney, M. D. Two-dimensional combinatorial screening of a bacterial rRNA A-site-like motif library: defining privileged asymmetric internal loops that bind aminoglycosides Biochemistry  2010 49:1833-1842  DOI:10.1021/bi901998m  PMID:20108982  PMCID:PMC2846769
  • Disney, M. D., Labuda, L. P., Paul, D. J., Poplawski, S. G., Pushechnikov, A., Tran, T., Velagapudi, S. P., Wu, M., Childs-Disney, J. L. Two-dimensional combinatorial screening identifies specific aminoglycoside - RNA internal loop partners Journal of the American Chemical Society  2008 130:11185-11194  DOI:10.1021/ja803234t  PMID:18652457
  • Adalid-Peralta, L., Godot, V., Colin, C., Krzysiek, R., Tran, T., Poignard, P., Venet, A., Hosmalin, A., Lebon, P., Rouzioux, C., Chene, G., Emilie, D., et al. Stimulation of the primary anti-hiv antibody response by ifn-alpha in patients with acute hiv-1 infection Journal of Leukocyte Biology  2008 83:1060-1067  DOI:10.1189/jlb.1007675  PMID:18182457  PMCID:PMC4749666
  • Gong, Q., Ou, Q. L., Ye, S. M., Lee, W. P., Cornelius, J., Diehl, L., Lin, W. Y., Hu, Z. L., Lu, Y. M., Chen, Y. M., Wu, Y., Meng, Y. G., et al. Importance of cellular microenvironment and circulatory dynamics in b cell immunotherapy Journal of Immunology  2005 174:817-826  PMID:15634903