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Transfer of ovine experimental allergic glomerulonephritis (eag) with serum

Academic Article
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Overview

authors

  • Lerner, Richard
  • Dixon, F. J.

publication date

  • 1966

journal

  • Journal of Experimental Medicine  Journal

abstract

  • Serum globulin from donor sheep made nephritic by immunization with glomerular basement membrane and subsequently nephrectomized contained specific kidney-fixing antibody and was capable of inducing an immediate, although transient, glomerulonephritis when injected into unilaterally nephrectomized lambs. This nephritis was characterized by immediate proteinuria, PMN infiltration into the glomerulus, and localization of gammaG- and beta1C-globulins in a linear fashion along the recipients' glomerular capillary walls. The nephritogenic property of the serum could be absorbed in vitro with isolated sheep glomerular basement membranes.

subject areas

  • Animals
  • Autoimmune Diseases
  • Basement Membrane
  • Glomerulonephritis
  • Hypersensitivity
  • Microscopy, Fluorescence
  • Nephrectomy
  • Serum Globulins
  • Sheep
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Identity

PubMed Central ID

  • PMC2138241

International Standard Serial Number (ISSN)

  • 0022-1007

Digital Object Identifier (DOI)

  • 10.1084/jem.124.3.431

PubMed ID

  • 5922743
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Additional Document Info

start page

  • 431

end page

  • 442

volume

  • 124

issue

  • 3

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