recent publications

• academic article

  • Wendt-Pienkowski, E., Huang, Y., Zhang, J., Li, B. S., Jiang, H., Kwon, H. J., Hutchinson, C. R., Shen, B. Cloning, sequencing, analysis, and heterologous expression of the fredericamycin biosynthetic gene cluster from streptomyces griseus Journal of the American Chemical Society  2005 127:16442-16452  DOI:10.1021/ja054376u  PMID:16305230
  • Rafanan, E. R., Hutchinson, C. R., Shen, B. Triple hydroxylation of tetracenomycin a2 to tetracenomycin c involving two molecules of o-2 and one molecule of h2o Organic Letters  2000 2:3225-3227  PMID:11009387
  • Shen, B., Hutchinson, C. R. Deciphering the mechanism for the assembly of aromatic polyketides by a bacterial polyketide synthase Proceedings of the National Academy of Sciences of the United States of America  1996 93:6600-6604  DOI:10.1073/pnas.93.13.6600  PMID:8692863
  • Summers, R. G., Ali, A., Shen, B., Wessel, W. A., Hutchinson, C. R. Malonyl-coenzyme a-acyl carrier protein acyltransferase of streptomyces-glaucescens - a possible link between fatty-acid and polyketide biosynthesis Biochemistry  1995 34:9389-9402  DOI:10.1021/bi00029a015  PMID:7626609
  • Shen, B., Summers, R. G., Wendtpienkowski, E., Hutchinson, C. R. The streptomyces-glaucescens tcmkl polyketide synthase and tcmn polyketide cyclase genes govern the size and shape of aromatic polyketides Journal of the American Chemical Society  1995 117:6811-6821  DOI:10.1021/ja00131a002
  • Shen, B., Hutchinson, C. R. Triple hydroxylation of tetracenomycin-a2 to tetracenomycin-c in streptomyces-glaucescens - overexpression of the tcmg gene in streptomyces-lividans and characterization of the tetracenomycin-a2 oxygenase Journal of Biological Chemistry  1994 269:30726-30733  PMID:7982994
  • Shen, B., Hutchinson, C. R. Enzymatic-synthesis of a bacterial polyketide from acetyl and malonyl coenzyme-a Science  1993 262:1535-1540  DOI:10.1126/science.8248801  PMID:8248801
  • Shen, B., Nakayama, H., Hutchinson, C. R. Isolation and structural elucidation of tetracenomycin-f2 and tetracenomycin-f1 - early intermediates in the biosynthesis of tetracenomycin-c in streptomyces-glaucescens Journal of Natural Products  1993 56:1288-1293  DOI:10.1021/np50098a013  PMID:8229013
  • Shen, B., Hutchinson, C. R. Tetracenomycin f1-monooxygenase - oxidation of a naphthacenone to a naphthacenequinone in the biosynthesis of tetracenomycin-c in streptomyces-glaucescens Biochemistry  1993 32:6656-6663  DOI:10.1021/bi00077a019  PMID:8329392
  • Shen, B., Hutchinson, C. R. Tetracenomycin-f2 cyclase - intramolecular aldol condensation in the biosynthesis of tetracenomycin-c in streptomyces-glaucescens Biochemistry  1993 32:11149-11154  DOI:10.1021/bi00092a026  PMID:8218177
  • Hutchinson, C. R., Decker, H., Guilfoile, P., Shen, B., Summers, R., Wendt-Pienkowski, E., Wessel, B. Polyketide synthases: enzyme complexes and multifunctional proteins directing the biosynthesis of bacterial metabolites from fatty acids Environmental Science Research  1992 44:3-10
  • Shen, B., Summers, R. G., Gramajo, H., Bibb, M. J., Hutchinson, C. R. Purification and characterization of the acyl carrier protein of the streptomyces-glaucescens tetracenomycin-c polyketide synthase Journal of Bacteriology  1992 174:3818-3821  PMID:1592832  PMCID:PMC206074