Scripps VIVO scripps research logo

  • Index
  • Log in
  • Home
  • People
  • Organizations
  • Research
  • Events
Search form
As of April 1st VIVO Scientific Profiles will no longer updated for faculty, and the link to VIVO will be removed from the library website. Faculty profile pages will continue to be updated via Interfolio. VIVO will continue being used behind the scenes to update graduate student profiles. Please contact helplib@scripps.edu if you have questions.
How to download citations from VIVO | Alternative profile options

Position and time specify the migration of a pioneering population of olfactory bulb interneurons

Academic Article
uri icon
  • Overview
  • Research
  • Identity
  • Additional Document Info
  • View All
scroll to property group menus

Overview

authors

  • Tucker, E. S.
  • Polleux, Franck
  • LaMantia, A. S.

publication date

  • September 2006

journal

  • Developmental Biology  Journal

abstract

  • We defined the cellular mechanisms for genesis, migration, and differentiation of the initial population of olfactory bulb (OB) interneurons. This cohort of early generated cells, many of which become postmitotic on embryonic day (E) 14.5, differentiates into a wide range of mature OB interneurons by postnatal day (P) 21, and a substantial number remains in the OB at P60. Their precursors autonomously acquire a distinct identity defined by their position in the lateral ganglionic eminence (LGE). The progeny migrate selectively to the OB rudiment in a pathway that presages the rostral migratory stream. After arriving in the OB rudiment, these early generated cells acquire cellular and molecular hallmarks of OB interneurons. Other precursors--including those from the medial ganglionic eminence (MGE) and OB--fail to generate neuroblasts with similar migratory capacity when transplanted to the LGE. The positional identity and migratory specificity of the LGE precursors is rigidly established between E12.5 and E14.5. Thus, the pioneering population of OB interneurons is generated from spatially and temporally determined LGE precursors whose progeny uniquely recognize a distinct migratory trajectory.

subject areas

  • Animals
  • Cell Movement
  • Embryo, Mammalian
  • Female
  • Immunohistochemistry
  • Interneurons
  • Male
  • Mice
  • Mice, Inbred ICR
  • Olfactory Bulb
  • Prosencephalon
  • Protein Structure, Tertiary
  • Telencephalon
  • Time Factors
scroll to property group menus

Research

keywords

  • development
  • forebrain
  • ganglionic eminence
  • interneuron
  • migration
  • neurogenesis
  • olfactory bulb
  • rostral migratory stream
scroll to property group menus

Identity

International Standard Serial Number (ISSN)

  • 0012-1606

Digital Object Identifier (DOI)

  • 10.1016/j.ydbio.2006.05.009

PubMed ID

  • 16790240
scroll to property group menus

Additional Document Info

start page

  • 387

end page

  • 401

volume

  • 297

issue

  • 2

©2022 The Scripps Research Institute | Terms of Use | Powered by VIVO

  • About
  • Contact Us
  • Support