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Autoantibodies to alpha(iib)beta(3) in patients with chronic immune thrombocytopenic purpura bind primarily to epitopes on alpha(iib)

Academic Article
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Overview

authors

  • Mc Millan, Robert
  • Lopez-Dee, J.
  • Loftus, J. C.

publication date

  • April 2001

journal

  • Blood  Journal

abstract

  • Chronic immune thrombocytopenic purpura (ITP) is an autoimmune disease caused by platelet destruction resulting from autoantibodies against platelet surface proteins, particularly platelet glycoprotein IIb/IIIa (alpha(IIb)beta(3)). To localize the auto-epitopes on platelet alpha(IIb)beta(3), the binding of autoantibodies to Chinese hamster ovary (CHO) cells expressing either alpha(IIb)beta(3) or alpha(v)beta(3) was studied. Thirteen of 14 ITP autoantibodies bound only to CHO cells expressing alpha(IIb)beta(3). Because these 2 integrins have the same beta chain (beta(3)), these results show that most epitopes in chronic ITP are dependent on the presence of glycoprotein alpha(IIb.) (Blood. 2001;97:2171-2172)

subject areas

  • Adult
  • Aged
  • Animals
  • Antibody Specificity
  • Autoantibodies
  • Autoimmune Diseases
  • CHO Cells
  • Cricetinae
  • Cricetulus
  • Epitopes
  • Female
  • Flow Cytometry
  • Humans
  • Male
  • Middle Aged
  • Platelet Glycoprotein GPIIb-IIIa Complex
  • Purpura, Thrombocytopenic, Idiopathic
  • Receptors, Vitronectin
  • Splenectomy
  • Transfection
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Identity

International Standard Serial Number (ISSN)

  • 0006-4971

Digital Object Identifier (DOI)

  • 10.1182/blood.V97.7.2171

PubMed ID

  • 11264188
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Additional Document Info

start page

  • 2171

end page

  • 2172

volume

  • 97

issue

  • 7

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